宁心稳律汤治疗室性期前收缩合并抑郁症睡眠障碍的临床研究

发布时间：2018-01-01 01:37

本文关键词：宁心稳律汤治疗室性期前收缩合并抑郁症睡眠障碍的临床研究　出处：《安徽中医药大学》2016年硕士论文　论文类型：学位论文

【摘要】：目的:通过临床研究观察宁心稳律汤治疗室性期前收缩合并抑郁症睡眠障碍的临床治疗疗效。方法:1.分组:采用随机分组法,纳入室性期前收缩合并抑郁症睡眠障碍患者60例,分为研究组20例,参松组20例,对照组20例。研究组予以常规抗心律失常药物治疗加用宁心稳律汤,参松组予以常规抗心律失常药物治疗加用参松养心胶囊,对照组予以常规抗心律失常药物治疗。2.指标与疗效:治疗周期为4周,治疗前后分别监测患者24小时动态心电图(室性期前收缩频次、心率变异性),评估治疗前后的中医症候积分、汉密尔顿抑郁量表评分、匹兹堡睡眠质量指数量表评分及观察治疗前后安全指标的变化。结果:治疗后患者室性期前收缩频次、中医症候积分、汉密尔顿抑郁量表评分、匹兹堡睡眠质量指数量表评分较治疗前均有明显降低(P0.01),治疗后患者心率变异性(SDNN、SDANN、rMSSD、pNN50)水平均较治疗前升高(P0.01)。研究组各项疗效优于参松组及对照组。结论:1.宁心稳律汤能够明显减少患者的室性期前收缩的频次,对心率变异性有一定的影响;宁心稳律汤能够改善室性期前收缩合并抑郁症睡眠障碍患者的临床症状、抑郁状态及睡眠质量。2.宁心稳律汤治疗室性期前收缩合并抑郁症睡眠障碍在临床应用安全,疗效确切,值得临床推广。
[Abstract]:Objective: To observe the effect of Ningxin Decoction stable law therapeutic room contractions clinical depression sleep disorder combined through clinical research. Methods: 1. group randomly into ventricular contractions in 60 patients with depression sleep disorder, divided into study group 20 cases, 20 cases of loose ginseng group and control group in 20 cases. The study group were treated with Ningxin Decoction in the treatment of stable law conventional antiarrhythmic drugs, Shengsong group treated with conventional antiarrhythmic drugs plus Shensongyangxin capsule, the control group was given conventional antiarrhythmic drug treatment.2. index and curative effect: the treatment period of 4 weeks, with 24 hours Holter monitoring. Before and after treatment (ventricular contraction frequency, heart rate variability), TCM syndrome score evaluation before and after treatment, Hamilton depression scale, changes in Pittsburgh sleep quality index score and safety index were observed before and after treatment Results: Patients with ventricular premature systole period after treatment frequency, symptom scores, Hamilton depression scale, Pittsburgh sleep quality index scores were lower than before the treatment (P0.01), after treatment of patients with heart rate variability (SDNN, SDANN, rMSSD, pNN50) levels were higher than before treatment (P0.01) the study group. The curative effect is better than that of Shensong group and control group. Conclusion: 1. Ningxin Decoction can obviously reduce the stability of law in patients with premature ventricular contraction frequency, has certain influence on heart rate variability; Ningxin Decoction can improve the stability of the law of ventricular extrasystole with clinical symptoms in patients with depression sleep disorder. The state of depression and sleep quality.2. Ningxin Decoction stable law therapeutic room contractions associated with depression sleep disorder in safety, clinical curative effect, worthy of promotion.

【学位授予单位】：安徽中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259;R277.7

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