加减羌活胜湿汤治疗风湿型膝骨关节炎的临床疗效观察

发布时间：2018-01-01 07:50

本文关键词：加减羌活胜湿汤治疗风湿型膝骨关节炎的临床疗效观察　出处：《福建中医药大学》2017年硕士论文　论文类型：学位论文

【摘要】：目的:通过观察加减羌活胜湿汤对早中期风湿型膝骨关节炎的症状改善情况,评价其对风湿型膝骨关节炎的临床疗效和安全性,为临床治疗此种证型膝骨关节炎提供新的依据和选择。方法:收集2015年10月-2016年10月就诊于河南省洛阳正骨医院膝关节病科的早中期风湿型膝骨关节炎患者60例。以入组的先后顺序,采用随机数表法将研究病例随机分为试验组和对照组,每组各30例。其中试验组服用加减羌活胜湿汤,对照组服用双醋瑞因胶囊。两组治疗周期均为6周,于治疗前、治疗2周后、4周后和6周后等观察时点,检测并记录入组病例50m行走后膝关节疼痛视觉模拟量表(VAS)评分、以及膝关节WOMAC指数评分和膝骨关节炎症状分级量化评分等各项疗效评价指标及相关安全性指标,采用尼莫地平法评价两组总体疗效。应用SPSS20.0软件进行数据统计分析,比较两组的疗效和差异性。结果:治疗前后不同观察时点间VAS评分、WOMAC指数评分和膝骨关节炎症状评分比较,差异均有统计学意义(P0.05),存在时间效应。两组患者VAS评分、WOMAC指数评分和症状评分,组间差异有统计学意义(P0.05),存在分组效应。治疗2周后和4周后,试验组VAS评分、WOMAC指数评分和症状评分均低于对照组,差异均有统计学意义(P0.05)。治疗6周后,两组VAS评分、WOMAC指数评分和症状评分比较,差异无统计学意义(P0.05)。分组因素和时间因素存在交互效应(P0.05)。总体疗效分析,试验组3例痊愈,11例显效,13例有效,3例无效,总有效率90%;对照组4例痊愈,10例显效,14例有效,2例无效,总有效率93.3%。两组总体疗效比较无统计学差异(P0.05)。结论:本研究结果表明加减羌活胜湿汤和双醋瑞因胶囊对治疗早中期风湿型膝骨关节炎均有较好的疗效,均可明显减轻膝骨关节炎患者的疼痛、改善患者的生活质量。加减羌活胜湿汤可为早中期风湿型膝骨关节炎的治疗提供一种借鉴。
[Abstract]:Objective: To observe the modified Qianghuo Shengshi Decoction to improve the situation of early stage rheumatoid knee osteoarthritis symptoms, evaluation of rheumatic knee osteoarthritis clinical efficacy and safety, to provide a new basis for the selection of clinical syndromes in the treatment of knee osteoarthritis. Methods: from October 2015 to October in -2016 in Luoyang Bone-setting Hospital of Henan Province Department of the early stage of knee joint rheumatic patients with knee osteoarthritis in 60 cases. In the order of the group, using a random number table method to study cases were randomly divided into experimental group and control group, 30 cases in each group. The experimental group was given modified Qianghuo Shengshi decoction, the control group was given the treatment of Diacerein Capsules. Cycle two groups were 6 weeks. Before treatment, after 2 weeks of treatment, after 4 weeks and 6 weeks after the observation point, measure and record the patients after 50m walking knee pain visual analogue scale (VAS) score, the knee joint WOMAC Index score and knee osteoarthritis symptoms score of the clinical evaluation index and safety index, using nimodipine method to evaluate the overall efficacy of the two groups. SPSS20.0 software was used for statistical analysis of the data, and the curative effect were compared between the two groups before and after treatment. Results: the different observation points, VAS score, WOMAC index score and knee osteoarthritis symptoms scores, the differences were statistically significant (P0.05), the existence of time effect. Two groups of patients with VAS score, WOMAC index score and symptom score, there was significant difference between the groups (P0.05), there are effects. After 2 weeks of treatment and 4 weeks after the test group VAS score, WOMAC index scores and symptom scores were lower than the control group, the differences were statistically significant (P0.05). After 6 weeks of treatment, two groups of VAS score, WOMAC index score and symptom score, the difference was not statistically significant (P0.05). The grouping factors and There is an interaction effect between factors (P0.05). The overall curative effect analysis, test group 3 cases were cured, 11 cases were cured, 13 cases effective, 3 cases ineffective, the total efficiency of 90%; control group 4 cases were cured, 10 cases were cured, 14 cases effective, 2 cases ineffective, the total efficiency of 93.3%. two groups overall efficacy comparison statistical differences (P0.05). Conclusion: the results of this study show that the modified Qianghuo wet soup and Diacerein Capsules on the treatment of early stage rheumatoid knee osteoarthritis has good curative effect, can significantly reduce the pain of knee osteoarthritis patients, improve the patient's quality of life. And Qianghuo wet can provide a reference for treatment of early stage rheumatic knee osteoarthritis.

【学位授予单位】：福建中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R274.9

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