电针心经穴与非经非穴对rs-fMRI脑功能连接的影响

发布时间：2018-01-01 08:06

本文关键词：电针心经穴与非经非穴对rs-fMRI脑功能连接的影响　出处：《针刺研究》2017年03期 　论文类型：期刊论文

【摘要】：目的:观察电针心经穴与同节段非经非穴时脑功能连接的不同变化,为临床运用电针心经穴治疗相关疾病提供影像学依据。方法:将符合纳入标准的健康受试者随机分为电针心经穴组10例和电针非经非穴组10例,电针心经穴组电针右侧下极泉、少海、灵道、神门穴,电针非经非穴组电针右侧同节段非经非穴,以双侧后扣带回为种子点,采用静息态动能磁共振成像,分析两组不同状态脑功能连接的差异。结果:两组电针前静息状态下的脑功能连接未发现存在明显差异的脑区。电针心经穴与非经非穴时两组脑功能连接中相同的脑区为双侧中央后回、右顶下小叶、右额下回;电针心经穴组功能连接中特异性增强的脑区为左侧颞下回、右侧海马旁回,特异性新激活的脑区为左侧中央前回、右侧顶叶楔前叶、左侧顶叶角回、左侧枕下回、左侧脑岛(P0.05);电针非经非穴组功能连接特异性新激活脑区为左颞上回(P0.05)。结论:大脑在无任务的安静、清醒状态下存在一定的功能活动。两组脑功能连接中相同的脑区主要与初级感觉区及精细感觉控制区密切相关,提示电针刺激均可引起一般体感觉区和精细感觉控制区的激活。电针心经穴组功能连接特异性增强和新增脑区主要与认知、情感、记忆等高级认知功能相关,也包括与心血管功能相关的脑区,这些脑区的功能与心经穴的功能主治有紧密联系,推测电针心经穴对与高级认知功能及心血管功能等相关脑区功能连接的影响可能是其治疗精神、神志类及心血管疾病的中枢机制之一。
[Abstract]:Objective: to observe the different changes of brain functional connection between electroacupuncture of the heart meridian point and the same segment non-meridian point. Methods: healthy subjects who met the inclusion criteria were randomly divided into two groups: 10 patients in the electroacupuncture group and 10 patients in the non-meridian group. Electroacupuncture of the right lower pole spring, Shaohai, Lingdao, Shenmen acupoint and non-meridian non-acupoint group of electroacupuncture on the right side of the heart meridian acupoint group, with double lateral cingulate gyrus as the seed point, the resting kinetic energy magnetic resonance imaging was used. The differences of brain functional connections between the two groups were analyzed. Results:. There was no significant difference in brain function junction between the two groups in the resting state before electroacupuncture. The same brain area in the two groups was bilateral posterior central gyrus when the acupoints of the heart and the meridians were not acupoints. Right inferior parietal lobule, right inferior frontal gyrus; In the electroacupuncture group, the specifically enhanced brain regions were left subtemporal gyrus, right parahippocampal gyrus, left precentral gyrus, right parietal lobe anterior cuneate lobe and left parietal lobe angle gyrus. Left inferior occipital gyrus, left cerebral islet (P0.05); The functional connection-specific new activated brain area in non-acupoint group was left superior temporal gyrus (P0.05). Conclusion: the brain is quiet without task. The same brain regions in the two groups were mainly related to the primary sensory area and the fine sensory control area. The results suggest that electroacupuncture stimulation can activate the general somatosensory region and fine sensory control area. The specific enhancement of functional connection and the increase of new brain area in the electroacupuncture group are mainly related to the higher cognitive functions such as cognition emotion memory and so on. It also includes the brain regions related to cardiovascular function. The function of these brain regions is closely related to the function of the heart meridian. It is inferred that the effect of electroacupuncture on the functional connections of brain regions related to advanced cognitive function and cardiovascular function may be one of the central mechanisms for the treatment of mental, mental and cardiovascular diseases.
【作者单位】：湖南中医药大学第一附属医院;
【基金】：国家自然科学基金项目(No.81273861;81473754) 湖南省教育厅科学研究项目(No.13C696) 湖南省自然科学基金项目(No.11JJ 5078) 湖南省科学技术厅科技计划一般项目(No.2013SK 3091) 湖南省中医药科研计划项目(No.2016105)
【分类号】：R246
【正文快照】： 中医对心脑关系的认识一直颇具争议。在经脉与脏腑的对应关系中,至关重要的脑只列为奇恒之府无相对应的经脉,而心经的生理循行及病理变化均表明心经与心之间联系密切。现代医学研究表明,针灸穴位与神经系统有密切关系,特别是与大脑特定皮层功能有关,针刺信息既可以直接影响脑

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