5种中药注射液治疗恶性胸腔积液的网状Meta分析

发布时间：2018-01-01 16:37

本文关键词：5种中药注射液治疗恶性胸腔积液的网状Meta分析　出处：《中国药房》2017年33期 　论文类型：期刊论文

【摘要】：目的:系统评价艾迪注射液、复方苦参注射液、康莱特注射液、榄香烯注射液和鸦胆子油乳注射液治疗恶性胸腔积液(MPE)的疗效,为临床提供循证参考。方法:计算机检索PubMed、EMBase、Cochrane图书馆、相关期刊论文(CJFD)、万方数据库和中文科技期刊数据库,收集艾迪注射液、复方苦参注射液、康莱特注射液、榄香烯注射液和鸦胆子油乳注射液分别对比顺铂治疗MPE的随机对照试验(RCT),提取资料并按照改良的Jadad评分量表评价质量后,采用ADDIS 1.16.6统计软件进行网状Meta分析。结果:共纳入54项RCT,合计3 404例患者。所有研究均为双臂,总臂数为108。网状Meta分析结果显示,与顺铂相比,复方苦参注射液[OR=2.19,95%CI(1.30,3.76),P0.05]、榄香烯注射液[OR=3.55,95%CI(2.43,5.32),P0.05]和鸦胆子油乳注射液[OR=1.92,95%CI(1.34,2.76),P0.05]可以显著提高MPE患者有效率,差异均有统计学意义;两两比较显示,榄香烯注射液在提高MPE患者有效率方面显著优于艾迪注射液[OR=0.32,95%CI(0.17,0.56),P0.05]、康莱特注射液[OR=0.30,95%CI(0.13,0.68),P0.05]和鸦胆子油乳注射液[OR=1.85,95%CI(1.10,3.17),P0.05],差异均有统计学意义;概率排序为榄香烯注射液复方苦参注射液鸦胆子油乳注射液艾迪注射液=康莱特注射液=顺铂。与顺铂相比,艾迪注射液[OR=0.29,95%CI(0.16,0.54),P0.05]、复方苦参注射液[OR=0.44,95%CI(0.18,0.96),P0.05]、榄香烯注射液[OR=0.21,95%CI(0.10,0.44),P0.05]和鸦胆子油乳注射液[OR=0.41,95%CI(0.23,0.70),P0.05]可以显著提高MPE患者生存质量改善率,差异均有统计学意义;两两比较显示,榄香烯注射液在提高MPE患者生存质量改善率方面显著优于康莱特注射液[OR=4.84,95%CI(1.03,25.01),P0.05],差异有统计学意义;概率排序为榄香烯注射液艾迪注射液复方苦参注射液鸦胆子油乳注射液康莱特注射液顺铂。结论:5种中药注射液均能有效治疗MPE,改善患者生存质量,其中榄香烯注射液成为最有效干预措施的可能性最大。
[Abstract]:Objective: To evaluate the Addie injection, compound matrine injection, Kanglaite Injection, Elemene Injection and Brucea javanica oil emulsion injection in the treatment of malignant pleural effusion (MPE) effect, and provide evidence for clinical reference. Methods: We searched PubMed, EMBase, Cochrane library, Chinese Journal Full-text Database (CJFD), Wanfang database and Chinese science journals the database, a collection of Addie injection, compound matrine injection, Kanglaite Injection, Elemene Injection and randomized controlled trials of Brucea javanica oil emulsion were compared with cisplatin in the treatment of MPE (RCT), data were extracted according to the modified Jadad scale evaluation of the quality of the mesh, Meta ADDIS analysis by using 1.16.6 statistical software. Results: a total of 54 RCT were included. 3404 patients. All the studies were arms, arm number is 108. mesh Meta analysis results showed that compared with cisplatin, matrine injection The injection of [OR=2.19,95%CI (1.30,3.76, P0.05]), Elemene Injection [OR=3.55,95%CI (2.43,5.32), P0.05] and [OR=1.92,95%CI of Brucea javanica oil emulsion (1.34,2.76), P0.05] can significantly improve the efficiency of MPE patients, there were statistically significant differences; 22 shows Elemene Injection in improving the efficiency of MPE patients was significantly higher than that of Addie injection [OR=0.32,95%CI (0.17,0.56), P0.05], Kanglaite Injection [OR=0.30,95%CI (0.13,0.68), P0.05] and [OR=1.85,95%CI of Brucea javanica oil emulsion (1.10,3.17), P0.05], the difference has statistical significance; probability ranking for Elemene Injection Fufangkushen injection of Brucea javanica oil emulsion injection Addie = Kanglaite Injection = cisplatin. Compared with cisplatin injection, Addie [OR=0.29,95%CI (0.16,0.54), P0.05], [OR=0.44,95%CI matrine injection (0.18,0.96), P0.05] Elemene Injection, [OR=0.21,95% CI (0.10,0.44), P0.05] and [OR=0.41,95%CI of Brucea javanica oil emulsion (0.23,0.70), P0.05] can significantly improve the quality of life of patients with MPE improvement rate, there were statistically significant differences; 22 shows Elemene Injection in improving the quality of life of patients. The improvement rate of MPE was significantly higher than that of Kanglaite Injection [OR=4.84,95%CI (1.03,25.01), P0.05], the difference was statistically significant; the probability ranking Elemene Injection Addie injection of compound matrine injection of Brucea javanica oil emulsion Kanglaite Injection cisplatin. Conclusion: 5 kinds of traditional Chinese medicine injection was effective in the treatment of MPE, improve the quality of life of patients, which Elemene Injection has become the most effective intervention measures the maximum likelihood.

【作者单位】：天津市中医药研究院附属医院;天津市第一中心医院;天津医科大学临床医学院;
【分类号】：R273
【正文快照】： 恶性胸腔积液(Malignant pleural effusion,MPE)是恶性肿瘤的常见并发症之一,几乎所有肿瘤均可导致MPE,其中超过75%的MPE是由肺癌、乳腺癌、卵巢癌及淋巴瘤转移至胸膜引起,但是仍有10%的MPE找不到原发肿瘤灶[1]。临床上恶性肿瘤患者一旦出现MPE,即意味着病变已到晚期,如不及时

【相似文献】