喜炎平联合热毒宁注射液对重症手足口病合并脑炎患儿的免疫水平影响

发布时间：2018-01-01 19:45

本文关键词：喜炎平联合热毒宁注射液对重症手足口病合并脑炎患儿的免疫水平影响　出处：《中药药理与临床》2017年04期 　论文类型：期刊论文

【摘要】：目的:探讨喜炎平联合热毒宁注射液对重症手足口病合并脑炎患儿的免疫修复作用。方法:收集临床确证的手足口病合并脑炎患儿72例,随即分为对照组(N=36)和观察组(N=36),观察组除了常规的退烧,补液及补充维生素C之外给予热毒宁注射液(0.6~0.8ml/kg/d)和喜炎平(0.2~0.4ml/kg)静脉滴注,对照组仅给予热毒宁注射液0.6~0.8ml/kg/d静脉滴注,7日一疗程,1次/日,治疗结束后,比较两组疗效,并对治疗前后两组患者的血清免疫球蛋白及补体、外周血T细胞淋巴亚群及血清细胞因子水平进行检测并比较。结果:观察组患儿总有率(97.22%)和痊愈率(75.00%)均明显高于对照组患儿(86.11%和55.56%),副作用发生率显著低于对照组;与对照组治疗后相比,观察组治疗后血清免疫球蛋白IgA、IgG及补体C4水平显著高于对照组治疗后;与对照组治疗后相比,观察组治疗后CD3+T%、CD4~+T%、CD8~+T%及CD4~+/CD8值较对照组治疗后显著升高;观察组治疗后IL-6,IL-10水平显著低于对照组治疗后水平。结论:喜炎平对手足口病合并脑炎患儿免疫损伤具有修复作用,临床疗效确切。
[Abstract]:Objective: to investigate the immunoremediation effect of Xiyanping combined with Reduning injection on severe hand-foot-mouth disease complicated with encephalitis. Methods: 72 cases of hand-foot-mouth disease complicated with encephalitis were collected. Then they were divided into two groups: control group (n = 36) and observation group (n = 36). In addition to redox and vitamin C supplementation, RDNI was given 0.6 ~ 0. 8ml / kg / d) and XYP0. 2 ~ 0. 4 ml / kg) intravenously. In the control group, only 0.6 ~ 0.8ml / kg 路kg ~ (-1) / d of Retinine injection was given intravenously, and a course of treatment was given once a day on 7th. After the treatment, the curative effect was compared between the two groups. The serum immunoglobulin and complement of the two groups before and after treatment were also studied. Results: the total rate of lymphoid subsets and serum cytokines in the observation group were significantly higher than those in the control group (97.22%) and 75.00% (P < 0.05). 86.11% and 55.56). The incidence of side effects was significantly lower than that in the control group. Compared with the control group, the levels of serum immunoglobulin IgG and complement C4 in the observation group were significantly higher than those in the control group after treatment. Compared with the control group, the values of CD8 ~ T% and CD4 ~ / CD8 in the CD3 T+ T of the observation group were significantly higher than those in the control group after treatment. The level of IL-6 IL-10 in the observation group was significantly lower than that in the control group. Conclusion: Xiyanping can repair the immune injury in children with hand-foot-mouth disease and encephalitis.
【作者单位】：许昌市第二人民医院;
【分类号】：R272
【正文快照】： 手足口病(简称HFMD),是由肠道病毒EV71引起的儿科疾病,多发于婴幼儿中,尤以3岁以下发病最多。主要临床表现为发热及手足口腔丘斑疹、疱疹和溃疡。重症患者可并发脑炎,心肌损害,循环衰竭及神经损害[1,2]。多数患者症状较轻,少数患者合并神经性肺水肿及脑炎等严重症状可导致死亡

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