复方丹参滴丸对胸痹（冠心病心绞痛）气滞血瘀证患者中心动脉压的影响

发布时间：2018-01-01 21:50

本文关键词：复方丹参滴丸对胸痹（冠心病心绞痛）气滞血瘀证患者中心动脉压的影响　出处：《南京中医药大学》2017年硕士论文　论文类型：学位论文

【摘要】：目的:复方丹参滴丸是临床上缓解心绞痛的常用中成药,但关于其对血压影响的研究较少。本研究通过对比观察两组气滞血瘀型胸痹(冠心病心绞痛)患者,在分别含服复方丹参滴丸和硝酸甘油片1-5min内,中心动脉压的变化,探讨复方丹参滴丸对中心动脉压的影响。方法:于2016年6月-2017年2月江苏省中西医结合医院心内科病房内,选取冠状动脉造影检查诊断冠心病并符合中医胸痹气滞血瘀证诊断的心绞痛患者60例,将其随机分成2组,每组30例。经过患者知情同意,在冠状动脉造影术中,给予治疗组患者舌下含服复方丹参滴丸10粒,对照组患者硝酸甘油片,0.5mg/次,并通过有创血压监测主动脉根部血压即中心动脉压,分别记录患者服药前以及服药后1min、2min、3min、4min、5min各时间点数值,运用SPSS软件进行统计分析,比较两种药物对中心动脉压的影响。结果:研究结果显示,(1)治疗组患者在含服复方丹参滴丸后1-5min内,和服药前相比,中心动脉压无明显变化(P0.05)。(2)对照组患者在含服硝酸甘油后2-5min内,中心动脉压明显低于服药前(P0.05)。(3)组间比较结果表明,服用两种药物在1-3mim内对患者中心动脉压的整体影响差异无统计学意义(P0.05)。在4min和5min时,硝酸甘油组患者的收缩压明显低于复方丹参滴丸组(P0.05)。舒张压各时间点两种药物比较均无统计学意义的差异(P0.05)。结论:复方丹参滴丸舌下含服后对中心动脉压无影响,硝酸甘油片舌下含服后对中心动脉压影响波动较大。
[Abstract]:Objective: Compound Danshen dripping pill is commonly used in Chinese medicine clinical remission angina, but the research about its effects on blood pressure is less. This study observed two groups of qi stagnation and blood stasis obstruction by contrast (angina pectoris) in patients with Compound Danshen Pill and Nitroglycerin Tablets 1-5min, the change of central arterial pressure, to investigate the effect of Compound Danshen Pill on central arterial pressure. Methods: in June 2016 -2017 year in February in Jiangsu Province Traditional Chinese Medicine Hospital Department of cardiology ward, selected coronary angiography in diagnosis of coronary heart disease and 60 patients with angina pectoris of qi stagnation and blood stasis syndrome with traditional Chinese medicine syndrome were diagnosed, were randomly divided into 2 groups, 30 cases in each group. After informed consent of patients. In coronary angiography, the patients in the treatment group were given sublingual administration of Compound Danshen Dripping Pills 10 pills, the control group with Nitroglycerin Tablets, 0.5mg/, and the invasive blood pressure monitoring of aorta The root of blood pressure is central arterial pressure, the patients were recorded before treatment and 1min after treatment, 2min, 3min, 4min, 5min values at each time point, using SPSS software for statistical analysis, comparison of two kinds of drugs on central arterial pressure. Results: the results showed that (1) patients in the treatment group with Compound Danshen after dropping 1-5min, compared and before treatment, no significant changes in central blood pressure (P0.05). (2) patients in the control group after taking nitroglycerin 2-5min, central arterial pressure was significantly lower than that before treatment (P0.05). (3) comparison between groups showed that taking the overall effects of two drugs on patients with pressure central artery in 1-3mim showed no significant difference (P0.05). In 4min and 5min, nitroglycerin group systolic blood pressure was significantly lower than that of Compound Danshen dripping pill group (P0.05). The diastolic blood pressure at each time point of the two drugs were no difference of statistical significance (P0.05). Conclusion: Compound Dan After sublingual administration of Shen dropping pill, there is no effect on central arterial pressure. The influence of Nitroglycerin Tablets under sublingual administration on central arterial pressure fluctuates greatly.

【学位授予单位】：南京中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R256.22

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