肝豆灵片治疗肝豆状核变性痰瘀互结证的疗效观察

发布时间：2018-01-03 11:09

本文关键词：肝豆灵片治疗肝豆状核变性痰瘀互结证的疗效观察　出处：《中国实验方剂学杂志》2017年15期 　论文类型：期刊论文

【摘要】：目的:观察肝豆灵片治疗肝豆状核变性痰瘀互结证的疗效,并探讨其作用机制。方法:将76例肝豆状核变性痰瘀互结证患者随机分为对照组和观察组,各38例,两组均给予西医基础治疗[二巯基丙磺酸钠(DMPS)和葡萄糖酸锌片],观察组加用肝豆灵片,治疗6个疗程后观察两者临床疗效。观察治疗前后两组中医证候积分,改良Goldstein分级,24 h尿铜(urine copper,u-Cu),游离铜(non-ceruloplasmin plasma copper,nCP-Cu)水平、肝功能和血常规等指标。结果:中医证候疗效总有效率对照组为60.53%,观察组为81.58%,观察组优于对照组(P0.01)。临床疗效总有效率对照组为73.68%,观察组为84.21%,观察组优于对照组(P0.05)。与治疗前比较,治疗后两组患者n CP-Cu水平明显降低(P0.05),u-Cu水平显著升高(P0.01);治疗后两组无统计学差异。与治疗前比较,两组患者血清总胆红素(total bilirubin,TBIL),天门冬氨酸氨基转移酶(aspartate aminotransferase,AST)和丙氨酸氨基转移酶(alanine amino-transferase,ALT)水平显著降低(P0.01);治疗后与对照组比较,观察组TBIL,AST和ALT水平明显降低(P0.05)。结论:肝豆灵片能显著改善肝豆状核变性痰瘀互结证患者中医证候,提高临床疗效,同时改善肝功能,且安全性高。
[Abstract]:Objective: to observe the efficacy and mechanism of Ganduoling tablet in treating phlegm and blood stasis syndromes of hepatolenticular degeneration. Methods: 76 cases of liver lenticular degeneration with phlegm and blood stasis syndrome were randomly divided into control group and observation group. Each 38 cases, both groups were given western basic treatment. [Sodium dimercaptopropanesulfonate (DMPS) and zinc gluconate tablets were used in the observation group. After 6 courses of treatment, the clinical effects of the two groups were observed, and the TCM syndromes scores of the two groups were observed before and after treatment. The improved Goldstein grading was used for 24 h urinary copper urine copperine u-Cu. The level of free copper (non-ceruloplasmin plasma coppern CP-Cu). Results: the total effective rate of TCM syndromes was 60.53 in the control group and 81.58% in the observation group. The total effective rate was 73.68 in the control group, 84.21 in the observation group, and better in the observation group than in the control group. After treatment, the level of n CP-Cu in the two groups was significantly lower than that in the control group (P 0.05) and the level of u-Cu was increased significantly (P 0.01). There was no statistical difference between the two groups after treatment. Compared with before treatment, total bilirubin total bilirubin TBILwas in the serum of the two groups. Aspartate aminotransferase. The levels of AST and alanine amino-transferase (alt) decreased significantly (P 0.01). Compared with the control group, the levels of TBILN AST and ALT in the observation group were significantly lower than those in the control group (P 0.05). Conclusion: Gandouling tablets can significantly improve the syndrome of phlegm and blood stasis syndromes in patients with hepatolenticular degeneration and phlegm stasis. Improve clinical efficacy and improve liver function, and high safety.
【作者单位】：安徽中医药大学第一附属医院;安徽中医药大学中医临床学院;
【基金】：国家自然科学基金青年基金项目(81202691)
【分类号】：R277.7
【正文快照】： [网络出版地址]http://kns.cnki.net/kcms/detail/11.3495.R.20170511.0936.054.html[网络出版时间]2017-05-11 9:36肝豆状核变性(Wilson's disease,WD)是一种常染色体隐性遗传的铜代谢障碍疾病,致病基因ATP7B定位于染色体13q14.3,编码一种铜转运P型ATP酶。ATP7B基因突变导致A

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