补肾活血膏方治疗支气管哮喘临床缓解期的临床观察及对FeNO的干预作用

发布时间：2018-01-03 13:19

本文关键词：补肾活血膏方治疗支气管哮喘临床缓解期的临床观察及对FeNO的干预作用　出处：《南京中医药大学》2017年硕士论文　论文类型：学位论文

【摘要】：目的探讨补肾活血膏方对支气管哮喘临床缓解期患者的ACT评分、血清IgE、肺功能(FEV1%和PEF%)、呼出气一氧化氮(FeNO)的影响。观察补肾活血膏方对支气管哮喘临床缓解期的临床疗效及对FeNO的干预情况。方法1.门诊选取支气管哮喘属于临床缓解期患者共60例,随机分为30例治疗组和30例对照组。分别测定两组患者的FeNO值,同时测定患者的ACT评分、血清IgE、肺功能(FEV1%和PEF%)等指标并记录作为参考。2.治疗组予补肾活血膏方联合吸入信必可,一日两次,一次一吸,时间为45天左右,后继续信必可吸入治疗,共为期6个月;对照组单纯吸入信必可治疗,为期6个月随访。疗程结束后再次比对FeNO、ACT评分、血清IgE、肺功能(FEV1%和PEF%)等指标。结果1.两组患者在ACT的评分、FeNO的水平、血清IgE、肺功能(PEF%)等指标的治疗前后比较中,有显著的统计学差异(P0.01),提示治疗有显著效果。但肺功能(FEV1%)治疗后较前未见明显改善。2.两组间比较,治疗组FeNO、肺功能(PEF%)、血清IgE下降治疗后较对照组改善更明显(P0.05)。结论补肾活血膏方治疗哮喘临床缓解期患者能降低FeNO的数值,在临床症状改善、肺功能(PEF%)、血清IgE等指标均优于单纯信必可吸入治疗。一定程度上体现了中医治疗哮喘的优势,阐明其现代科学依据。
[Abstract]:Objective to study the ACT score, serum IgE, pulmonary function, FEV1% and PEF5 of Bushen Huoxue Ointment in patients with bronchial asthma. Exhaled nitric oxide (Feno). To observe the clinical effect of Bushen Huoxue Ointment on bronchial Asthma in remission period and its intervention on FeNO. 1. Totally 60 cases of bronchial Asthma were selected from outpatient clinic. Patients were randomly divided into treatment group and control group. The FeNO, ACT score and serum IgE were measured respectively. Pulmonary function, FEV1% and PEF) were recorded and recorded as reference .2.The treatment group was given Bushen Huoxue Ointment combined inhalation of Bushen Huoxue Ointment, twice in 1st, once a time, the time was about 45 days. To continue inhalation therapy for a total of 6 months; Patients in the control group were treated with inhaled cinnabine and followed up for 6 months. After the course of treatment, the FeNol ACT score and serum IgE were compared again. Results 1.The ACT scores, serum IgE and pulmonary function were compared between the two groups before and after treatment. 2. There was a significant statistical difference (P 0.01), indicating that the treatment had a significant effect, but the pulmonary function and FEV1 after treatment did not show significant improvement. 2. 2. Comparison between the two groups, the treatment group FeNO. Compared with the control group, the decrease of serum IgE was significantly improved by P0.05.Conclusion Bushen Huoxue Ointment can reduce the value of FeNO in patients with asthma in clinical remission period. In the improvement of clinical symptoms, pulmonary function and serum IgE were better than that of Xinji inhalable therapy, which to some extent reflected the superiority of TCM in treating asthma and clarified its modern scientific basis.
【学位授予单位】：南京中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R256.12

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