清脑益元汤对缺血性中风患者血清BDNF、NGF、VEGF水平的影响

发布时间：2018-01-04 00:31

本文关键词：清脑益元汤对缺血性中风患者血清BDNF、NGF、VEGF水平的影响　出处：《广西中医药大学》2016年硕士论文　论文类型：学位论文

【摘要】：目的:探讨清脑益元汤治疗缺血性中风的临床疗效及其对患者血清脑源性神经营养因子(BDNF)、神经生长因子(NGF)及血管内皮生长因子(VEGF)水平的影响。方法:选取缺血性中风患者60例,按随机数字表法随机分为治疗组与对照组,每组30例,对照组予以单纯西医常规治疗,治疗组在对照组基础上加用清脑益元汤,14天为1个疗程,两组均治疗1个疗程,治疗前后评价两组神经功能缺损评分及中医症候积分,观察临床疗效及血清BDNF、NGF、VEGF的表达水平。结果:(1)治疗前,两组神经功能缺损评分、中医症状积分及血清BDNF、NGF、VEGF水平比较,差异均无统计学意义(P0.05);(2)治疗组与对照组治疗总有效率和中医症候疗效总有效率分别为93.3%、75.8%和90%、62.1%,差异有统计学意义(P0.05),其疗效明显优于对照组;(3)治疗后,两组神经功能缺损评分及中医症候积分均较治疗前降低(P均0.01),血清BDNF、NGF、VEGF水平比较均较治疗前升高(P均0.01);(4)治疗组神经功能缺损评分及中医症候积分均明显低于对照组(P均0.05),血清NGF、BDNF和VEGF水平均显著高于对照组(P均0.01)。结论:清脑益元汤能明显改善缺血性中风患者神经功能缺损程度,其机制可能与提高缺血性中风患者血清BDNF、NGF、VEGF水平有关。
[Abstract]:Objective: to investigate the clinical effect of Qingnao Yiyuan decoction (QNYD) in treating ischemic apoplexy and its effect on serum brain-derived neurotrophic factor (BDNF). Methods: 60 patients with ischemic stroke were randomly divided into treatment group and control group. Each group of 30 cases, the control group was given simple western routine treatment, the treatment group on the basis of the control group plus Qingnao Yiyuan decoction for 14 days as a course of treatment, both groups were treated with a course of treatment. Before and after treatment, the neurological deficit score and TCM symptom score were evaluated, and the clinical efficacy and the expression of serum BDNF NGF FU VEGF were observed. There was no significant difference in neurological deficit score, TCM symptom score and serum level of BDNFN NGF VEGF between the two groups (P 0.05). The total effective rate of treatment group and control group and the total effective rate of TCM symptoms were 93.3% and 90.8%, respectively. The difference was statistically significant (P 0.05). The curative effect was better than that of the control group. After treatment, the neurological impairment score and TCM symptom score in both groups were lower than those before treatment (P 0.01), and serum BDNF NGF was decreased. The level of VEGF was higher than that before treatment (P < 0.01). (4) the scores of nerve function defect and TCM symptom in the treatment group were significantly lower than those in the control group (P < 0.05), and the serum NGF was significantly lower than that in the control group (P < 0.05). The levels of BDNF and VEGF were significantly higher than those of control group (P < 0.01). Conclusion: Qingnao Yiyuan decoction can obviously improve the degree of nerve function defect in patients with ischemic stroke. The mechanism may be related to the increase of serum BDNF-NGF-VEGF level in ischemic stroke patients.
【学位授予单位】：广西中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R277.7

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