基于系统聚类分析总结吴良村辨治结直肠癌经验

发布时间：2018-01-04 05:32

本文关键词：基于系统聚类分析总结吴良村辨治结直肠癌经验　出处：《中华中医药杂志》2017年01期 　论文类型：期刊论文

【摘要】：目的:总结吴良村辨治结直肠癌的用药规律。方法:文章纳入2011年7月1日-2014年6月30日吴良村教授门诊304例结直肠癌患者,608诊次,将患者临床信息转化为方剂基础数据库,对药物累计频数、药物性味采用描述性分析,对频数最高的50种药物进行系统聚类分析。结果:304例患者608诊次共用药224种,累计用药频次11 506,其中用药频次最多者为茯苓,其后依次为鸡内金、白术、山药、藤梨根、白花蛇舌草、石斛、甘草。药性使用频次最多的为"平",药味使用频次最多的为"甘"。聚类分析将药物分为21类,涉及方剂四君子汤,药对知母和生地黄、炒稻芽和麦芽、太子参和炒薏苡仁、杜仲和天麻等。结论:吴良村辨治结直肠癌以健脾益气为主,随证辅以熄风通络、活血化瘀、解毒抗癌、消食和中之法,临证用药善于甘、苦、辛、平配伍。
[Abstract]:Objective: To summarize the treatment medication rule of Wu Liang Cun colorectal cancer. Methods: the article in the July 1, 2011 June 30th -2014 Professor Wu Liang Cun outpatient 304 cases of colorectal cancer, 608 cases of patients with clinical information, will be transformed into the basic database of prescription drugs, drugs of cumulative frequency, descriptive analysis, cluster analysis on the frequency of 50 the highest drug. Results: 304 cases of patients with 608 cases of 224 kinds of common drugs, drug cumulative frequency of 11506, which is the most frequent use of Fuling, followed by chicken, white atractylodes rhizome, Chinese yam, tengligen, Oldenlandia, Dendrobium, licorice. The most frequently used drugs for "flat", the most frequently used herbs the "sweet". The drugs are divided into 21 groups by cluster analysis, involving four prescription drugs on Sijunzi Decoction, Rhizoma Anemarrhenae and radix rehmanniae, fried malt and rice sprouts, ginseng and coix seed, eucommia and Gastrodia. Conclusion: Wu Liang Cun resolution Treatment of colorectal cancer with Spleen Qi, with the aid of xifengtongluo, blood stasis, detoxification cancer, and the digestion method, clinical medicine is sweet, bitter, pungent, and flat.

【作者单位】：浙江省立同德医院;浙江省中医院;
【基金】：浙江省中医药科学研究基金项目(No.2014ZA036,No.2014ZB029)~~
【分类号】：R249;R273
【正文快照】： 结直肠癌(colorectal cancer,CRC)是第三大恶性肿瘤,其导致病死的患者占所有恶性肿瘤病死人数的8.6%[1]。CRC的西医治疗,目前以手术切除为主,辅以化疗、放疗、靶向等综合方法,单纯外科手术治疗患者5年生存率约为50%[2]。但CRC起病隐匿,50%-60%的患者确诊时已是局部晚期(Ⅱ、Ⅲ

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