蓝芩口服液治疗慢性咽炎随机对照试验的系统评价和Meta分析

发布时间：2018-01-04 21:04

本文关键词：蓝芩口服液治疗慢性咽炎随机对照试验的系统评价和Meta分析　出处：《中国中药杂志》2017年08期 　论文类型：期刊论文

【摘要】：系统评价蓝芩口服液治疗慢性咽炎的疗效和安全性。计算机检索Pub Med,Embase,Cochrane Library,CBM,CNKI,VIP,万方科技数据库,收集蓝芩口服液治疗慢性咽炎的随机对照研究,检索时限均为从建库至2017年3月,由2名研究者按照纳入和排除标准独立进行文献筛选、资料提取,用Cochrane偏倚评估手册进行质量评价并交叉核对。采用Rve Man.5.3软件进行数据分析。共纳入13个随机对照试验,共计1 642例慢性咽炎患者。Meta分析结果显示:1有效率:蓝芩口服液治疗组优于对照组(常规治疗或其他药物治疗);2IL-2:蓝芩口服液治疗组优于对照组(MD及95%CI,2.20[1.91,2.48],P0.000 01);3TNF-α:蓝芩口服液治疗组优于对照组(MD及95%CI,0.75[0.60,0.90],P0.000 01);4不良反应:无安全性信息报告。基于现有临床证据,蓝芩口服液治疗慢性咽炎的有效率优于常规治疗或其他药物治疗。但由于纳入研究的方法学质量普遍较低,需要严格方法学设计和质量控制的临床研究提供高质量的证据。
[Abstract]:The system to evaluate the efficacy and safety of Lanqin oral liquid in the treatment of chronic pharyngitis. Retrieved from Pub Med, Embase Cochrane, Library, CBM, CNKI, VIP, Wanfang database technology, collection of randomized controlled studies of Lanqin oral liquid in the treatment of chronic pharyngitis, were searched from inception to March 2017, by 2 researchers in accordance with the inclusion and exclusion criteria independently screened the literatures, extracted the data and assessed the quality of Cochrane bias assessment manual and cross check. Data were analyzed by Rve Man.5.3 software. A total of 13 RCTs, a total of 1642 cases of.Meta patients with chronic pharyngitis analysis results showed that: 1 the efficiency of control group: treatment group was better than that of Lanqin oral liquid (conventional therapy or other drug treatment); control group 2IL-2: treatment group was better than that of Lanqin oral liquid (MD and 95%CI, 2.20[1.91,2.48], P0.000 01); 3TNF-: alpha Lanqin oral liquid in treatment group than in control group (MD 0.75[0.60,0.90], P0.000 and 95%CI, 01); 4 adverse reactions: no information security report. The existing clinical evidence based on Lanqin oral liquid in the treatment of chronic pharyngitis with efficiency is superior to conventional therapy or other medication. But because of methodological quality is generally low, need strict methodology of clinical research design and quality control to provide high quality evidence.

【作者单位】：天津中医药大学;天津中医药大学循证医学中心;
【基金】：教育部新世纪优秀人才项目(NCET-13-0936) 天津市131创新人才培养工程第三层次项目
【分类号】：R276.1
【正文快照】： 慢性咽炎是指咽喉部黏膜的慢性炎症,是临床上常见病症,具有病程长、反复发作等特点,主要是因细菌、病毒等因素长期刺激所致,多发于成年人[1]。慢性咽炎患者的临床表现主要有咽部疼痛、有异物感、发痒及咳嗽等,尤其是在晨起刷牙时会出现反射性的恶心、欲吐等现象,影响患者及其

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