基于眼跳数据的抑郁症肝气郁证患者抑郁眼神探究

发布时间：2018-01-05 05:10

本文关键词：基于眼跳数据的抑郁症肝气郁证患者抑郁眼神探究　出处：《山东中医药大学》2016年硕士论文　论文类型：学位论文

【摘要】：目的:(1)抑郁症是一种常见的情感障碍性疾病,抑郁情志的客观测评是国内外医学界多年研究尚未解决的难题。望眼神可以读懂内心的情绪以及情感体验。眼睛的运动状态即眼动是眼神中的关键因素。现代有关研究表明眼动异常是抑郁症患者抑郁情绪的主要眼神特征。因此,本研究在此基础上,采用SMI眼动追踪系统,对抑郁症肝气郁证患者正向和反向眼跳数据进行记录,旨在为抑郁症抑郁情志的客观测评提供新方法。(2)中医学认为抑郁症肝气郁证与肝失疏泄,气机郁滞,情志失调密切相关,但具体病变机制,科学内涵不清。开展抑郁症肝气郁证患者眼动研究可以部分说明该病证产生的中枢机制,并为肝主疏泄调畅情志的机制研究提供新途径,为肝藏象功能机制及其活体结构的揭示提供基础资料。方法:本研究由山东省精神卫生中心专科医生筛选抑郁症肝气郁证患者(36人)为抑郁症组,匹配正常个体(36人)为对照组,共两组被试,实验使用SMI公司i View X RED 500型眼动仪,采用反眼动实验范式,对两组被试正向和反向眼跳数据进行记录和分析。结果:(1)在正向眼跳任务中,抑郁症组与对照组组间基本不存在显著性差异;总体来讲,两组的峰速度、平均速度及眼跳幅度位置主效应显著,(F=6.538,P=0.002)(F=32.83,P=0.000)(F=24.23,P0.0001),随着角度的增大,抑郁症组和对照组都呈现出更快的峰速度、平均速度和眼跳幅度。(2)反向眼跳任务中,对照组与抑郁症组的正确率存在显著性差异(t=3.219,P=0.002),平均速度位置主效应显著(F=8.225,P=0.004)(F=4.708,P=0.032);其他指标没有显著性差异。(3)Anti效应结果分析中,两组的潜伏期与正确率、精确性方向主效应显著(F=67.44,P0.0001)(F=272.1,P0.0001)(F=79.02,P0.0001);与正向眼跳相比,抑郁症组与对照组在反向眼跳中都表现出更长的潜伏期及更差的正确率和精确性。结论:实验发现抑郁症肝气郁证患者抑制功能明显差于正常人,所以眼跳任务可以作为客观测评抑郁症抑制功能的良好工具。涉及的相关脑区也可以部分说明肝疏泄失常所致抑郁症肝气郁证患者抑郁情志产生的中枢机制,从而为肝主疏泄调畅情志机制研究提供了新途径,为肝藏象功能机制及其活体结构的揭示提供了基础资料。
[Abstract]:Objective: (1) depression is a common emotional disorder, depressive emotion is the objective evaluation of the medical profession at home and abroad for many years of unresolved problems. Looking eyes can read emotions and emotional experience. The motion state of the eye eye movement is a key factor in the eyes. Modern research shows that abnormal eye movement is the main features of eyes of depression in patients with depression. Therefore, on this basis, using SMI eye tracking system, recording of depression of liver qi stagnation syndrome patients with positive and antisaccade data, to objective evaluation for depression depression emotion. (2) provide a new method of medicine of stagnation of liver qi depression and liver dysfunction, qi stagnation, emotional disorders are closely related, but the specific pathological mechanism, scientific connotation is not clear. To carry out the depression of liver qi stagnation syndrome patients with eye movement study may partly explain this syndrome produced The central mechanism, and provide a new way for the research on the mechanism of liver regulating emotions, like to reveal the function mechanism and its in vivo structure to provide the basic data for the liver. Methods: This study by the health center of Shandong province psychiatric doctors screening of patients with depression of liver qi stagnation syndrome (36), depression group, normal individuals (36 people) as the control group, a total of two subjects, using SMI I View X the RED 500 eye tracker, the eye movement paradigm, recording and analysis of subjects of the two groups of forward and reverse saccade data. Results: (1) in the forward saccade task, the depression group and control group there is no significant difference; in general, the peak speed of two groups, the average saccade amplitude and velocity position has significant main effect, (F=6.538, P=0.002) (F=32.83, P=0.000) (F=24.23, P0.0001), as the angle increases, the depression group and control group showed a faster The peak velocity, mean velocity and saccade amplitude. (2) antisaccade task, the correct rate of control group and depression group have significant difference (t=3.219, P=0.002), the average speed of position has significant main effect (F=8.225, P=0.004) (F=4.708, P=0.032); other indicators have no significant difference. (3) the Anti effect results, two groups of latency and accuracy, the accuracy of the direction of significant main effect (F=67.44, P0.0001) (F=272.1, P0.0001) (F=79.02, P0.0001); compared with the positive saccade, depression group and control group in the antisaccade have showed longer latency and accuracy worse and accurate. Conclusion: the experiment found that patients with depression of liver qi stagnation syndrome inhibitory function was significantly worse than normal people, so a good tool for saccade task can be used as the objective evaluation of depression inhibitory function. Related brain areas involved can also be part of the liver qi depression of liver dysfunction The central mechanism of qi stagnation syndrome patients with depressive emotion is generated, which provides a new way for the liver regulating emotion mechanism, function mechanism and living like to reveal the structure and provide basic information for the liver.

【学位授予单位】：山东中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R277.7

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