复方泽漆冲剂联合走罐疗法治疗斑块型银屑病的疗效观察

发布时间：2018-01-08 02:18

  本文关键词：复方泽漆冲剂联合走罐疗法治疗斑块型银屑病的疗效观察　出处：《安徽中医药大学》2016年硕士论文　论文类型：学位论文

  更多相关文章： 斑块型银屑病 复方泽漆冲剂 走罐疗法 疗效观察

【摘要】：1目的探讨复方泽漆冲剂联合走罐疗法治疗静止期斑块型银屑病的有效性及安全性,综合评价复方泽漆冲剂联合走罐疗法的临床价值,以便后期临床推广。2方法将62例符合纳入标准的斑块型银屑病患者按随机数字表法分为治疗组和对照组,两组各31例。治疗组予复方泽漆冲剂口服,外用凡士林软膏,同时在皮损部位进行走罐疗法。对照组予复方泽漆冲剂口服加凡士林软膏外用。2周为1疗程,共治疗4个疗程。治疗2周后、4周后、6周后、8周后分别进行PASI评分及瘙痒程度评分,并于疗程结束后比较两组患者皮损单项体征严重程度评分、中医证候评分、DLQI评分、疾病疗效,同时观察整个研究过程中有无不良反应。3结果3.1本研究疗程结束后,治疗组有1人因工作外调无法严格按照就诊时间来院就诊,对照组有1人在治疗期间服用其他药物,故脱落2人,最终有60例患者完成临床研究疗程,两组各30例。两组治疗前皮损单项体征严重程度评分、PASI评分、瘙痒程度评分、中医证候评分、DLQI评分均无统计学差异(P值均大于0.05),具有可比性。3.2比较两组患者皮损单项体征严重程度评分,与各自治疗前相比,治疗组与对照组均能改善皮损鳞屑、浸润、红斑体征(P均小于0.05);两组组间比较,治疗组在改善皮损鳞屑体征方面优于对照组(P值等于0.006),两组在改善皮损浸润及红斑体征方面疗效相当(P值均大于0.05)。3.3两组患者治疗2周后、4周后、6周后、8周后PASI评分分别与各自治疗前比较,均有统计学差异(P值均小于0.05),治疗组与对照组均能降低患者PASI评分;从治疗4周后,两组间比较,P值均小于0.05,这说明,从治疗4周后,治疗组的在降低患者PASI评分方面优于对照组。3.4两组患者治疗2周后、4周后、6周后、8周后的瘙痒程度评分分别与各自治疗前比较,均有统计学差异(P值均小于0.05),治疗组与对照组均能改善患者瘙痒症状;从治疗4周后,两组间比较P值均小于0.05,这说明,从治疗4周后,治疗组在改善患者瘙痒症状方面优于对照组。3.5比较两组患者治疗前后中医证候评分,与各自治疗前相比,治疗组与对照组均能改善斑块型银屑病患者血瘀症状(P值均小于0.05);两组组间比较,治疗组改善血瘀症状的疗效优于对照组(P值等于0.015)。3.6比较两组患者治疗前后DLQI评分,与各自治疗前相比,治疗组与对照组均能改善斑块型银屑病患者的生活质量(P值均小于0.05);两组组间比较,治疗组改善斑块型银屑病患者的生活质量的疗效优于对照组(P值等于0.006)。3.7比较两组患者临床疗效:治疗组治愈3人,显效13人,有效8人,无效6人,显效率53.33%,总有效率80%。对照组治愈1人,显效7人,有效10人,无效12人,显效率27.67%,总有效率60%。具有统计学差异(P值等于0.028),治疗组疗效优于对照组。3.8治疗期间,治疗组有1例出现胃脘部不适,1例出现月经量增多,对照组有1例出现轻微腹泻。两组不良反应发生率分别为6.67%、3.33%,差异无统计学意义(P值大于0.05)。4结论复方泽漆冲剂联合走罐疗法治疗静止期斑块型银屑病疗效确切,且无明显不良反应,值得临床推广。
[Abstract]:Objective to investigate 1 compound Zeqi Granules Combined with walking safety and efficacy of cupping therapy in the treatment of static plaque psoriasis, comprehensive evaluation of the clinical value of combined compound Zeqi granules walking cupping therapy, in order to promote.2 in late stage clinical methods 62 patients met the inclusion criteria of plaque psoriasis were randomly divided into treatment group and control the two group, 31 cases in each group. The treatment group was treated with compound Zeqi granules oral, topical Vaseline ointment and workingcan in skin lesions. The control group were treated with compound Zeqi granules plus Vaseline oral topical.2 weeks for 1 courses, a total of 4 courses of treatment. After 2 weeks of treatment, after 4 weeks, 6 weeks, the scores of PASI and pruritus degree were performed after 8 weeks and after treatment were compared between the two groups of single sign lesion severity score, TCM syndrome score, DLQI score, clinical efficacy, and observe the whole research process There is no adverse reaction to the end of the course of 3.1.3 results in this study, the treatment group of 1 people for work in strict accordance with the treatment time to transfer to the hospital, the control group had 1 people taking other drugs during treatment, so the loss of 2 people, finally 60 patients completed the clinical study on the treatment of two, 30 cases in each group. Two before treatment, skin lesions signs of severity score, PASI score, pruritus score, TCM syndrome score, DLQI score were not statistically significant (P values were greater than 0.05), with more than two groups of.3.2 lesions of patients with signs of severity score, compared with those before treatment, the treatment group and control group can improve the scaly skin lesions, infiltration, signs of erythema (P < 0.05); comparison between the two groups, the treatment group in improving the symptoms of scaly skin lesions than the control group (P = 0.006), the two groups in the improvement of skin erythema infiltration and signs of equivalent efficacy (P values were 澶т簬0.05).3.3涓ょ粍鎮ｈ，

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