针刺大鼠“相对穴”阳陵泉与阴陵泉对P物质表达的影响研究

发布时间：2018-01-08 07:34

本文关键词：针刺大鼠“相对穴”阳陵泉与阴陵泉对P物质表达的影响研究　出处：《中国中医基础医学杂志》2017年08期 　论文类型：期刊论文

【摘要】：目的:观察针刺大鼠相对穴阴陵泉与阳陵泉后穴区局部和血清中P物质(SP)的表达,探讨SP变化与"相对穴"协同增效的相关性。方法:除空白对照组外,其他各组大鼠给予电针干预后采用酶联免疫技术检测实验前后大鼠血清中SP含量,穴区局部组织组化染色观察穴区SP阳性表达。结果:与对照组比较,其他各针刺组穴区局部SP阳性表达和血清中含量均有不同程度的增多,其中针刺相对穴阳陵泉与阴陵泉穴组SP表达最为显著,各针刺组比较,针刺旁开阳陵泉与阴陵泉穴组SP表达显著低于其他各组。结论:针刺相对穴阳陵泉与阴陵泉穴SP穴区局部阳性表达和血清含量显著增高,是相对穴配伍协同增效的可能因素之一。
[Abstract]:Objective: To observe the acupuncture points of rats relative yinlingquan and Yanglingquan after local acupoints and serum substance P (SP) expression, to explore the relationship between the change of SP and the "relative points" synergy. Methods: except the blank control group, rats in other groups were given electroacupuncture intervention by enzyme-linked immune detection technology before and after the experiment in rats serum SP content, acupoint local tissue were observed on the positive expression of SP. Results: compared with the control group, the increase in other local SP acupuncture group positive expression and serum content in varying degrees, including acupuncture and acupuncture Yanglingquan relative yinlingquan acupoints group SP expression obviously, the acupuncture group, acupuncture at Kaiyang Ling Quan Yin Ling Quan acupoint group and the expression of SP was significantly lower than that of the other groups. Conclusion: acupuncture point relative gb34and yinlingquan acupoints SP acupoint local expression and serum were significantly increased, which is on the acupoints in coordination One of the possible factors for increasing efficiency.

【作者单位】：承德医学院;华北理工大学;河北省中药研究与开发重点实验室承德医学院;
【基金】：河北省自然科学基金资助项目(H2014406047)-相对穴对MC趋经穴募集及细胞间通讯的作用机制研究河北省高等学校科学技术研究重点项目(ZD20131001)-相对穴协同增效的细胞和分子作用机制研究
【分类号】：R245
【正文快照】： P物质(substance P,SP)是一种广泛分布于神经系统和其他周围各组织器官的小分子神经非阿片肽,参与多种生命活动的调控,不仅参与免疫、生殖内分泌等调节,还在痛觉传递、胃肠蠕动、神经保护、呼吸运动、血管扩张、伤口愈合等方面起着举足轻重的作用[1-2],同时也是针刺效应产生的

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