青石止痒软膏联合消风止痒汤加减治疗神经性皮炎的疗效评价

发布时间：2018-01-11 12:35

本文关键词：青石止痒软膏联合消风止痒汤加减治疗神经性皮炎的疗效评价　出处：《中国实验方剂学杂志》2017年21期 　论文类型：期刊论文

【摘要】：目的:观察青石止痒软膏联合消风止痒汤加减辨证治疗神经性皮炎的临床疗效,及对瘙痒介质和炎症因子的影响。方法:将160例患者随机按数字表法分为西医组和中医组各80例。西医组外用糠酸莫米松乳膏,均匀涂于患处,每天早晚各1次;口服氯雷他定片,10 mg/次,1次/d。中医组外用青石止痒软膏,将药物轻揉于患处,每天早晚各1次;内服消风止痒汤加减,1剂/d,两组疗程均为21 d。进行治疗前后瘙痒程度采用视觉模拟评分(VAS),皮损程度采用湿疹面积及严重度指数(EASI)评分,中医证候评分,生活质量采用皮肤病生活质量(DIQL)量表评价,检测治疗前后5-羟色胺(5-HT),组胺,P物质(SP),β-内啡肽(β-EP),白细胞介素-6(IL-6),IL-8和肿瘤坏死因子-α(TNF-α)水平。结果:中医组临床疗效总有效率为95.95%,高于西医组的84.93%(χ~2=5.173,P0.05);中医组中医证候疗效总有效率为95.95%,高于西医组的78.08%(χ2=10.419,P0.01);治疗后中医组患者的瘙痒VAS,EASI,中医证候和DIQL评分均低于西医组(P0.01);治疗后中医组5-HT,组胺,SP,β-EP水平均低于西医组(P0.01);治疗后中医组IL-6,IL-8和TNF-α水平均低于西医组(P0.01)。结论:与西医常规治疗方案相比较,采用消风止痒汤加减内服联合青石止痒软膏外用治疗神经性皮炎能减轻患者瘙痒,改善皮损症状,降低中医证候评分,提高患者的生活质量,能调节引起瘙痒的化学介质和免疫炎症因子,临床疗效和中医证候疗效均优于西医常规疗法。
[Abstract]:Objective: to observe the clinical effect of Qingshi Zhiyang ointment combined with Xiaofeng Zhiyang decoction on neurodermatitis. Methods: 160 patients were randomly divided into western medicine group (n = 80) and traditional Chinese medicine group (n = 80). 1 time in the morning and evening; Oral Loratadine 10 mg / time 1 / d. Chinese medicine group external use of Qingshi antipruritic ointment, the drug gently rubbed in the affected area, once a day in the morning and evening; Oral administration of Xiaofengzhi itching decoction 1 / d, the two courses of treatment were 21 days. The degree of pruritus before and after treatment was assessed by visual analogue score (VASS). Eczema area and severity index (EASI), TCM syndrome score and quality of life (QOL) were used to evaluate the degree of skin lesions. Before and after treatment, serotonin 5-HT, histamine substance P, 尾 -endorphin (尾 -EPN) and interleukin-6 (IL-6) were detected. Results: the total effective rate of TCM group was 95.95, which was higher than that of western medicine group (84.93%, 蠂 2, 5.173). P0.05; The total effective rate of TCM syndromes in TCM group was 95.95, which was higher than 78.08 in Western medicine group (蠂 2 10.419 P 0.01). After treatment, the pruritus of patients in the TCM group was lower than that in the western medicine group (P 0.01), and the scores of TCM syndromes and DIQL were lower than those in the western medicine group. After treatment, the levels of 5-HT, histamine SPand 尾 -EP in TCM group were lower than those in western medicine group (P 0.01). After treatment, the levels of IL-6, IL-8 and TNF- 伪 in TCM group were lower than those in western medicine group (P 0.01). The treatment of neurodermatitis with Xiaofengzhi itching decoction combined with Qingshi Zhiyang ointment can reduce the pruritus, improve the symptom of skin lesion, reduce the score of TCM syndrome, and improve the quality of life of the patients. It can regulate the chemical mediators and immune inflammatory factors that cause pruritus. The clinical curative effect and TCM syndromes effect are better than that of western medicine routine therapy.
【作者单位】：北京中医药大学东方医院;
【基金】：北京市科技计划课题项目(Z131100002513013)
【分类号】：R275.9
【正文快照】： [网络出版地址]http://kns.cnki.net/kcms/detail/11.3495.R.20170809.1125.040.html[网络出版时间]2017-08-09 11:25神经性皮炎(neurodermatitis)也称慢性单纯性苔藓,以阵发性剧烈瘙痒和皮肤苔藓样变为特征的顽固性慢性炎性皮肤病,皮损局限性或泛发性。其治疗棘手,病情反复难

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