小儿病毒性上呼吸道感染采用小儿豉翘清热颗粒治疗疗效观察

发布时间：2018-01-11 17:46

本文关键词：小儿病毒性上呼吸道感染采用小儿豉翘清热颗粒治疗疗效观察　出处：《中华中医药学刊》2017年05期 　论文类型：期刊论文

【摘要】：目的:探讨小儿病毒性上呼吸道感染采用小儿豉翘清热颗粒治疗疗效。方法:截选2015年1月—2016年1月86例小儿病毒性上呼吸道感染患者按照随机数字表法分组为对照组[利巴韦林颗粒,10 mg/(kg·d),分2~3次服用]与治疗组(小儿豉翘清热颗粒,6个月~1岁,1~2 g/次,1~3岁,2~3 g/次,3~7岁,3~4 g/次;均为3次/d),各43例。记录两组患儿开始退热时间、完全退热时间,统计两组临床疗效及不良反应,并评价两组患儿治疗前、后中医证候积分变化;检测两组患儿治疗前、后血清肿瘤坏死因子α(TNF-α)、白细胞介素-6(IL-6)水平。结果:治疗组患儿开始退热时间、完全退热时间分别为(5.49±4.13)h、(9.20±3.75)h明显短于对照组(22.14±8.67)h、(25.48±12.25)h,P0.05;两组患儿治疗后血清TNF-α、IL-6水平及中医证候积分明显低于治疗前,治疗组治疗后血清TNF-α、IL-6水平及中医证候积分明显低于对照组,P0.05。治疗组治疗总有效率86.05%,明显高于对照组58.14%,P0.05。治疗期间均无严重性不良反应,未影响本次研究结果。结论:采用小儿豉翘清热颗粒治疗小儿病毒性上呼吸道感染疗效显著且安全,可推荐为患儿治疗首选药物。
[Abstract]:Objective: to investigate the therapeutic effect of infantile viral upper respiratory tract infection with Xiaojiajiaoqingre granule. 86 children with viral upper respiratory tract infection from January 2015 to January 2016 were divided into control group according to random number table. [Ribavirin granules, 10 mg/(kg 路dg, were taken twice and 3 times) and treated with the treatment group (Xiaojiaokao Qingre granules, 6 months old, 1 year old, 1g / time, 1 year old, 2g / d), and treatment group (6 months old, 1 year old, 1 year old, 1 year old, 1 year old, 3 g / time). The age of 7 years old was 3g / time; All of them were 3 times / d, 43 cases each. The time of beginning and complete antipyrexia of the two groups was recorded, the clinical curative effect and adverse reaction of the two groups were counted, and the changes of TCM syndromes integral before and after treatment were evaluated. The serum levels of TNF- 伪 and IL-6 were measured before and after treatment in both groups. Results: the antipyretic time was observed in the treatment group. The total antipyretic time was 5.49 卤4.13 h (9.20 卤3.75 h), significantly shorter than that in the control group (22.14 卤8.67 h, 25.48 卤12.25 h). P0.05; The serum TNF- 伪 IL-6 level and TCM syndromes score were significantly lower in the two groups after treatment than before, and the serum TNF- 伪 after treatment in the treatment group. IL-6 level and TCM syndrome score were significantly lower than that of control group P0.05.The total effective rate of treatment group was 86.05, which was significantly higher than that of control group (58.14%). P0.05. there were no serious adverse reactions during the treatment, which did not affect the results of this study. Conclusion: the treatment of infantile viral upper respiratory tract infection with Xiaojiajiaoqingre granule is effective and safe. It can be recommended as the first choice in the treatment of children.
【作者单位】：温州医科大学附属第三医院儿科;温州医科大学附属第三医院中医儿科;
【分类号】：R272
【正文快照】： 急性上呼吸道感染主要是由各种病原菌所致喉部以上鼻和鼻咽及咽部的急性炎症,该疾病大约90.0%为病毒所致,常累及邻近器官和淋巴结等[1]。小儿病毒性上呼吸道感染是儿童时期常见疾病,目前临床西医主要以多饮水和休息及增强抵抗力等为主,尚无理想治疗药物。中医认为小儿病毒性上

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