针刺对乳腺癌新辅助化疗患者ER和PR表达的影响

发布时间：2018-01-11 19:32

本文关键词：针刺对乳腺癌新辅助化疗患者ER和PR表达的影响　出处：《云南中医学院》2016年硕士论文　论文类型：学位论文

【摘要】：目的:观察针刺对乳腺癌新辅助化疗患者ER和PR表达的影响。方法:根据随机数字表将符合病例纳入标准的72例患者随机分为针刺组(36例)和对照组(36例)。对照组采用乳腺癌的新辅助化疗治疗。新辅助化疗药物采用:诺维本。用法:静脉冲入30mg/平方米,1次/周。药物溶于125ml等渗盐水中,于15-20分钟内静脉输入。输液后,沿此静脉再输入250ml等渗盐水冲洗。新辅助化疗药物治疗4个周期。针刺组在采用乳腺癌新辅助化疗治疗的基础上同时给予针刺治疗,主穴采用膻中、三阴交、太冲、肩井、少泽、足三里。配穴采用辨证选穴,肝郁气滞型加肝俞;脾虚痰湿型加丰隆、阴陵泉;冲任失调型肾俞、命门、太溪;瘀毒内阻型加膈俞、合谷;气血双亏型加气海、血海。针刺组进行4周针刺治疗,每周3次。4周后分别观察两组患者ER和PR表达情况、患者生活质量和中医临床症状等。结果:(1)对照组、针刺组ER和PR表达情况比较,治疗前后ER、PR表达经统计学处理,无明显差异。(P㧐0.05)。(2)对照组、针刺组患者治疗前后组内比较生活质量评分,差异有统计学意义(P0.05)。两组患者治疗后组间比较生活质量评分,差异有统计学意义(P0.05)。表明患者在新辅助化疗4个周期内生活质量明显下降,针刺能明显改善患者因接受新辅助化疗导致的生活质量下降。(3)两组患者中医临床症状积分治疗前后比较差异均有统计学意义(P0.05)。两组患者治疗后进行组间比较差异有统计学意义(P0.05)。表明患者在新辅助化疗4个周期内中医临床症状积分明显下降,针刺能明显改善患者因接受新辅助化疗导致的中医临床症状积分下降。(4)安全性观察:两组患者在治疗期间均不同程度出现相应的化疗后不良反应。但对照组化疗后不良反应比针刺组严重,如体重减轻,脱发等。结论:选用诺维本进行4个周期的新辅助化疗对ER、PR的表达无明显影响;诺维本进行4个周期新辅助化疗的同时加用膻中、三阴交、太冲、肩井、少泽、足三里为主穴针刺对ER、PR的表达无明显影响;患者在新辅助化疗4个周期内生活质量明显下降,针刺能明显改善患者因接受新辅助化疗导致的生活质量下降;患者在新辅助化疗4个周期内中医临床症状积分明显下降,针刺能明显改善患者因接受新辅助化疗导致的中医临床症状积分下降。
[Abstract]:Objective: to observe the effect of acupuncture on ER and PR expression in breast cancer patients with neoadjuvant chemotherapy. Methods: according to the random digital table, 72 patients who met the criteria were randomly divided into acupuncture group (n = 36) and acupuncture group (n = 36). The control group was treated with neoadjuvant chemotherapy for breast cancer and the control group was treated with neoadjuvant chemotherapy. Once a week. The drug was dissolved in 125ml isoosmotic saline and was injected intravenously within 15-20 minutes. Four cycles of neoadjuvant chemotherapeutic drugs were used. Acupuncture group was treated with acupuncture on the basis of neoadjuvant chemotherapy therapy of breast cancer, and the main point was Tanzhong at the same time. Sanyinjiao, Taichong, shoulder-well, Shaoze, Zusanli. Points used to identify points, liver stagnation of Qi plus Ganshu; Spleen deficiency phlegm dampness type plus Fenglong, Yin Ling spring; Chong Ren dysfunctional Shen Yu, Mingmen, Taixi; Stasis toxin internal obstruction type plus Geshu, Hegu; Qi-blood double deficiency type plus air sea, Xuehai. Acupuncture group was treated with acupuncture for 4 weeks. After 4 weeks, the expression of ER and PR in the two groups were observed three times a week. Results the expression of ER and PR in control group and acupuncture group were compared, the expression of ERP PR was statistically treated before and after treatment, and there was no significant difference between control group and acupuncture group. In the control group, the scores of quality of life in the acupuncture group were compared before and after treatment, the difference was statistically significant (P 0.05). The scores of quality of life were compared between the two groups after treatment. The difference was statistically significant (P 0.05), which indicated that the quality of life of the patients decreased significantly during the four cycles of neoadjuvant chemotherapy. Acupuncture can significantly improve the quality of life of patients who received neoadjuvant chemotherapy. There was significant difference between the two groups after treatment, indicating that the scores of TCM clinical symptoms decreased significantly in the four cycles of neoadjuvant chemotherapy. Acupuncture can significantly improve the clinical symptoms of patients who received neoadjuvant chemotherapy. Safety observation: the two groups of patients in the treatment period of different degrees of adverse reactions after chemotherapy, but the control group after chemotherapy adverse reactions were more serious than acupuncture group. Conclusion: four cycles of neo-adjuvant chemotherapy with Norvibene have no significant effect on the expression of ERP. Novibene was treated with four cycles of neoadjuvant chemotherapy simultaneously with Tanzhong, Sanyinjiao, Taochong, shoulder well, Shaoze, Zusanli acupuncture had no significant effect on the expression of ERG PR. The quality of life (QOL) of patients with neoadjuvant chemotherapy decreased significantly in 4 cycles, and acupuncture could significantly improve the quality of life (QOL) of patients who received neoadjuvant chemotherapy. The clinical symptom score of Chinese medicine decreased significantly in 4 cycles of neoadjuvant chemotherapy, and acupuncture could obviously improve the decrease of clinical symptom score of Chinese medicine caused by neoadjuvant chemotherapy.
【学位授予单位】：云南中医学院
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R737.9

【相似文献】