基于正交设计法优化穴位贴敷防治支气管哮喘方案的研究

发布时间：2018-01-12 20:05

  本文关键词：基于正交设计法优化穴位贴敷防治支气管哮喘方案的研究　出处：《中国针灸》2017年06期 　论文类型：期刊论文

  更多相关文章： 哮喘 穴位贴敷 正交设计 影响因素

【摘要】：目的:研究过敏史、贴敷频次、贴敷时间对穴位贴敷防治支气管哮喘疗效影响的主次因素,并优化其治疗方案。方法:收集80例确诊为支气管哮喘的患者作为研究对象进行正交设计试验研究。药物选用我科历年的经验贴敷配方(白芥子、延胡索、生甘遂、细辛、麻黄、葶苈子、丁香、肉桂、牙皂按照2∶2∶1∶1∶1∶1∶1∶1∶1比例配成)。贴敷穴位取双侧肺俞、心俞、膈俞、肾俞。先按照有无过敏史分为两大组(有过敏史40例,无过敏史40例),再将两大组分别随机各分为4组,每组10例。通过研究三因素两水平,即有无过敏史(因素A:A_Ⅰ:有过敏史、A_Ⅱ:无过敏史)、不同贴敷频次(因素B:B_Ⅰ:4次、B_Ⅱ:10次,即贴敷4次的组每10天贴1次,贴敷10次的组每4天贴敷1次)、不同贴敷时间(因素C:C_Ⅰ:4 h、C_Ⅱ:8 h)对各组患者治疗前后同期哮喘发作次数和治疗前与治疗结束后6个月支气管哮喘生存质量量表(AQLQ)评分的差异筛选最优方案。结果:(1)正交试验表明,最优方案为A_ⅠB_ⅡC_Ⅰ,即有过敏史的患者,贴敷10次,每次保留4 h。(2)因素B(贴敷频次)、C(贴敷时间)为支气管哮喘AQLQ评分的显著影响因素(均P0.05)。(3)所有患者治疗前后哮喘发作次数、AQLQ评分的比较表明不同因素水平的组合对哮喘发作次数和AQLQ评分的影响不同,除了1组、5组之外,其他各组均有显著改善(P0.05,P0.01)。结论:穴位贴敷治疗哮喘可明显降低患者的发作次数,改善患者的生活质量;过敏史、贴敷频次、贴敷时间对疗效影响的主次关系为:贴敷频次贴敷时间过敏史;最优组合方案为:A_ⅠB_ⅡC_Ⅰ,即有过敏史的患者,贴敷10次,每次保留4 h。
[Abstract]:Objective: to study the influence of allergy history, frequency and time on the curative effect of acupoint application on bronchial asthma. Methods: 80 patients with bronchial asthma were selected as subjects for orthogonal design study. The medicine was applied to our department with the prescription of "White Mustard" and "Yanhusuo" in the past years. Kansui, Asarum, Ephedra Ephedra, Lepidii, clove, Cinnamon, and Tooth soap are made according to the ratio of 2: 2: 1: 1: 1: 1: 1: 1. Shenshu. According to the history of allergy, 40 cases had allergic history and 40 cases had no allergic history. Then the two groups were randomly divided into 4 groups, each group 10 cases. Through the study of three factors and two levels. There was no history of allergy (factor A: AI: history of allergy AII: no history of allergy), and different application frequency (factor B: BI: 4 times: BII: 10 times). That is, the group of 4 times of application was applied once every 10 days, and the group of 10 times of application was applied once every 4 days for different application time (factor C: C _ I: 4 h). C _ 鈪，

本文编号：1415771