基于气机变化理论对特发性肺纤维化的病机探讨

发布时间：2018-01-15 03:05

本文关键词：基于气机变化理论对特发性肺纤维化的病机探讨　出处：《中华中医药学刊》2017年09期 　论文类型：期刊论文

【摘要】：特发性肺纤维化是一种发病机制不明,致死致残率极高且目前临床疗效欠佳,是医疗界的棘手难题。在对IPF长期临床观察和实验研究下,发现该病同时存在着肺痹与肺痿的病机特点。从气机变化理论分析,在疾病的早期当属肺痹,以肺卫气虚、宗气不足、肺络痹阻为主要特点;在疾病的中晚期以肺痿为主,脾肾气虚、痰瘀胶结、络虚不荣;在疾病的慢性迁延期,存在着肺痹与肺痿的相互转化,不过痹与痿的侧重不同而已。
[Abstract]:Idiopathic pulmonary fibrosis (IPF) is a difficult problem in the medical field because of its unclear pathogenesis, high lethal and disability rate and poor clinical efficacy. Under the long-term clinical observation and experimental study of IPF. It was found that the disease had the characteristics of lung arthralgia and pulmonary impotence at the same time. According to the theory of the change of Qi, it was mainly characterized by deficiency of lung qi, deficiency of qi and obstruction of lung collaterals at the early stage of the disease. In the middle and late stage of the disease, mainly pulmonary impotence, spleen and kidney Qi deficiency, phlegm and blood stasis cementation, collateral deficiency is not proud; In the chronic delay period of the disease, there is the mutual transformation of lung arthralgia and pulmonary impotence, but the emphasis of arthralgia and impotence is different.
【作者单位】：云南中医学院;文山州中医医院;昆明市中医医院;
【基金】：国家自然科学基金项目(81360581) 云南省应用基础研究计划项目(2013FZ251) 云南省青年基金项目(2014FD100)
【分类号】：R259
【正文快照】： 特发性肺纤维化(Idiopathic Pulmonary Fibrosis,IPF)为一种特殊类型原因不明、出现在成人、局限于肺、慢性、进行性致纤维化的间质性肺炎,其组织病理学和(或)影像学符合普通间质性肺炎(Ussal Interstitial Pneumonia,UIP)。近年来,IPF发病率逐渐上升,男性多于女性,诊断后的中

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