基于系统药理学方法揭示维药复方西红花对心血管疾病治疗的分子机制

发布时间：2018-01-15 09:52

本文关键词：基于系统药理学方法揭示维药复方西红花对心血管疾病治疗的分子机制　出处：《西北大学》2016年硕士论文　论文类型：学位论文

【摘要】：近年来,心血管疾病以其惊人的发病率和致死率被称为“世界头号杀手”。该疾病相关的作用机制十分复杂,并且至今仍不清楚。中医药始终以从综合和整体的角度对抗复杂疾病为目的,并且在心血管疾病的治疗方面已经表现出良好的效果。然而,从系统层面上了解中药对于心血管疾病的多尺度治疗策略仍然是一个难题。因此,本研究以维药名方——-复方西红花治疗心血管疾病为例,运用系统药理学方法揭示中药治疗复杂疾病的潜在分子机制。首先,通过ADME筛选和药物靶点预测,我们获取了103个活性化合物以及对应的219个直接靶标,并且通过实验验证了某些关键的化合物靶点相互作用关系。基于以上工作,我们随之构建了活性化合物,靶点和疾病之间的相互关系,以此揭示维药复方西红花在治疗心血管疾病方面的药理作用。最后,我们将与心血管疾病相关的不同调控模块整合成一个“心血管疾病治疗通路”,以此揭示维药复方西红花在不同心血管疾病病理过程相关的生物过程层面对疾病的治疗效果。以上研究证明了维药复方西红花通过调控心血管疾病相关生物过程发挥其多尺度治疗活性,这也为现代医学治疗复杂疾病提供了一种新的潜在方法。
[Abstract]:In recent years, with its amazing cardiovascular disease morbidity and mortality is known as "the world's number one killer." the mechanism of disease is very complex, and is still not clear. Traditional Chinese medicine has always been to the comprehensive and holistic perspective against the complex disease for the purpose, and in the treatment of cardiovascular disease has been shown a good performance. However, from the system level to understand Chinese is still a difficult problem for multi scale treatment strategies for cardiovascular disease. Therefore, the research on Uygur medicine side - SM treatment of cardiovascular diseases as an example, reveal the molecular mechanisms underlying complex diseases using traditional Chinese medicine in the treatment of systematic pharmacological method. First, selected by ADME and drug target prediction, we obtain 219 direct target of 103 compounds and the corresponding, and through experimental verification of some key target compounds mutually The role of the relationship. Based on the above work, we will construct the active compounds, the relationship between the target and the disease, in order to reveal the pharmacological effects of Compound Safflower drug in treatment of cardiovascular diseases. Finally, we combine the different regulatory modules associated with cardiovascular disease are integrated into a "cardiovascular disease treatment pathway", in order to reveal the effect of compound saffron in different biological processes related to cardiovascular disease pathological process of the disease treatment. The above research proves that the Uygur medicine compound saffron by regulating the cardiovascular disease related biological processes play a multiscale therapeutic activity, which is the modern medical treatment of complex diseases and provide a potential new method.

【学位授予单位】：西北大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R29

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