乳腺癌术前中医证型与预后因素的相关性

发布时间：2018-01-15 21:40

本文关键词：乳腺癌术前中医证型与预后因素的相关性　出处：《实用医学杂志》2017年09期 　论文类型：期刊论文

【摘要】：目的:探讨乳腺癌患者术前中医辨证分型与预后因素的相关性。方法:对113例乳腺癌患者进行术前中医辨证分型,分为肝郁痰凝、冲任失调、正虚毒炽3个证型,术后对患者进行TNM分期、病理组织学分级,同时检测术后标本中ER、PR、VEGF的表达情况,进行分析。结果:3个证型中,肿瘤组织的ER、PR表达差异无统计学意义(P0.05);肝郁痰凝型TNM分期早,病理组织学分级、VEGF表达阳性率、淋巴结转移阳性率均较低,而正虚毒炽型TNM分期晚,病理组织学分级、VEGF表达阳性率、淋巴结转移阳性率均较高,且差异有统计学意义(P0.05)。结论:乳腺癌术前中医证型与TNM分期、病理组织学分级、VEGF表达、淋巴结转移情况有相关性,三个证型中,肝郁痰凝型预后最好,正虚毒炽型预后最差。
[Abstract]:Objective: to explore the correlation between preoperative TCM syndrome differentiation and prognostic factors in patients with breast cancer. Methods: 113 patients with breast cancer were divided into liver stagnation and phlegm coagulation disorder. After operation, the patients were divided into TNM stage and histopathological grade, and the expression of ERP TNM was detected and analyzed. Results: the three syndrome types were divided into three groups. There was no significant difference in ERP PR expression in tumor tissues (P 0.05). The TNM stage of liver stagnation and phlegm coagulation type was earlier, the positive rate of TNM and lymph node metastasis were lower in pathological grade, while the positive rate of TNM stage in positive deficiency and incandescent toxin type was late and histopathological grade. The positive rate of VEGF expression and lymph node metastasis were all high, and the difference was statistically significant (P 0.05). Conclusion: TCM syndrome type, TNM stage and histopathological grade of breast cancer before operation. The expression of VEGF and lymph node metastasis were correlated. Among the three syndromes, the type of liver stagnation and phlegm coagulation had the best prognosis, and the type with positive deficiency and incandescent toxin had the worst prognosis.
【作者单位】：中山大学肿瘤防治中心综合科;
【分类号】：R273
【正文快照】： 乳腺癌是女常见的恶性肿瘤之一,其发病率呈逐年上升的趋势[1],如今乳腺癌发病率已跃居女恶性肿瘤的第一位,严重危害女的健康[2]。乳腺癌的治疗虽然仍以手术治疗为首选,但人们注意到综合治疗的重要性。长期的临床实践和实验研究表明中医药有改善乳腺癌患者生存质量与抗肿瘤、预

【相似文献】