高血压心肌纤维化方剂处方规律分析

发布时间：2018-01-16 19:28

本文关键词：高血压心肌纤维化方剂处方规律分析　出处：《时珍国医国药》2017年09期 　论文类型：期刊论文

【摘要】：目的分析相关期刊论文(CNKI)收录治疗高血压心肌纤维化(myocardial fibrosis,MF)方剂的组方规律。方法收集CNKI收录治疗高血压心肌纤维化方剂,基于中医传承辅助平台(V2.5)分析处方用药规律。结果共筛选出73首方剂,涉及122味中药。方中补虚药出现频次最高(30.4%),其次是活血化瘀药(21.7%)、平肝息风药(17.4%);出现频率最高的药物是丹参(32.0%),药对是丹参-钩藤(23.3%)。关联分析结果显示,治疗高血压心肌纤维化方剂中,常用平肝息风-平肝息风药,活血化瘀-活血化瘀药,活血化瘀-平肝息风药物组合。演化得到核心组合8个,新处方4首。结论 CNKI收录治疗高血压心肌纤维化方剂组方以补肾、平肝、活血、利水化痰为主,以本病继发病同治,心肝肾并治,邪正兼顾,为中医药临床治疗高血压心肌纤维化提供有力参考。
[Abstract]:Objective to analyze the treatment of myocardial fibrosis (fibrosis) in patients with hypertension by CNKI (Chinese Journal Full-text Database). Methods the prescription of CNKI was collected for the treatment of hypertensive myocardial fibrosis. Results A total of 73 prescriptions were selected, involving 122 kinds of Chinese medicine. The highest frequency of tonifying and deficiency drugs appeared in the prescription was 30.4g). The second is the drug of activating blood circulation and removing blood stasis, and the medicine of calming the liver and relieving the wind is 17.4%. The most frequent drug was Salvia miltiorrhiza 32.0g, and the drug pair was Danshen Leptospira 23.30.Relational analysis showed that the prescription for the treatment of hypertensive myocardial fibrosis. Commonly used drugs for calming the liver, removing blood stasis, activating blood circulation and removing blood stasis, promoting blood circulation and removing blood stasis and calming the liver and relieving wind. Eight core combinations were obtained by evolution. Conclusion the prescription of CNKI for treating hypertensive myocardial fibrosis is mainly composed of tonifying kidney, calming the liver, promoting blood circulation, promoting water and resolving phlegm, treating the disease with the same disease, treating heart, liver and kidney, and taking account of evil. To provide a strong reference for the clinical treatment of hypertensive myocardial fibrosis.
【作者单位】：山东中医药大学;山东中医药大学中医学院;
【基金】：国家自然科学基金(No.81503539)
【分类号】：R259
【正文快照】： 心肌纤维化(myocardial fibrosis,MF)是指心肌组织结构中胶原纤维过量积聚、胶原浓度升高或胶原容积分数显著增加的一种病理变化[1]。MF是高血压性心脏病心肌重构的主要病理特征,与心力衰竭、心肌缺血、心律失常、猝死等密切相关[2]。预防和逆转MF,降低心血管并发症和病死率是

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