芪术通便汤治疗慢传输型便秘气虚证的临床研究

发布时间：2018-01-17 13:24

本文关键词：芪术通便汤治疗慢传输型便秘气虚证的临床研究　出处：《湖南中医药大学》2016年硕士论文　论文类型：学位论文

【摘要】：目的:观察芪术通便汤治疗气虚证慢传输型便秘患者的临床疗效及安全性,发挥中医药的优势,更好的为广大患者服务。方法:所选病例均来源于2015年01月至2016年02月,在湖南省中医院肛肠科就诊为气虚证慢传输型便秘的患者。按照临床随机分组的方法,将符合纳入标准的70例患者,随机分为治疗组和对照组;治疗组35例服用芪术通便汤治疗,对照组35例服用琥珀酸普芦卡必利片治疗,疗程均为4周。两组患者均以便秘症状积分、相关中医症状积分,作为疗效判定指标,对其分别进行治疗前后评估;对病例报告表记录的数据,运用SPASS19.0统计分析软件进行数据的分析及处理,并进行组内、组间比较。结果:最终获得统计分析的患者共66例,其中治疗组35例、对照组31例。两组便秘症状评估在便秘症状临床疗效评价方面:治疗组总有效率为97.14%,对照组总有效率为87.1%,经秩和检验(Z=-2.180,P0.05),治疗组改善患者便秘症状的总有效率明显优于对照组。治疗后两组症状总积分相比较,经t检验(t=-1.872,P=0.0420.05),两组差异有统计学意义,说明治疗组的整体的症候治疗优于对照组。各主要症状积分比较中,治疗组在“气短程度”、“乏力程度”、“少气懒言”、“纳差程度”这4方面治疗治疗均有P0.05,差异具有统计学意义,说明治疗组能够改善气虚症候。对照组在上4方面均有P0.05,差异无统计学意义,说明对照组不能改善气虚症候。在获得患者满意度方面,治疗组患者的满意率为91.43%。对照组满意率为77.42%,经秩和检验(Z=-1.969,p=0.0490.05).差异有统计学意义,说明治疗组能够获得患者的认可。两组在治疗过程中均未出现不良反应及毒副作用,说明用药安全性好。结论:1.芪术通便汤治疗气虚证慢传输型便秘的临床疗效效果确切,在治疗疗效、整体便秘症状、相关中医症状以及患者用药满意度方面优于琥珀酸普芦卡必利片.2.芪术通便汤临床应用未见不良反应及毒副作用。芪术通便汤是治疗气虚证慢传输型便秘安全有效中药方,值得进一步推广应用。
[Abstract]:Objective: to observe the clinical efficacy and safety of Qizhutongbian decoction in treating slow transit constipation of qi deficiency syndrome, and to give full play to the advantages of traditional Chinese medicine. Methods: the selected cases were from January 2015 to February 2016. According to the method of clinical randomized grouping, 70 patients who met the inclusion criteria were randomly divided into treatment group and control group. The treatment group (35 cases) were treated with Qizhu Tongbian decoction (QZT), the control group (35 cases) were treated with Pucapride Succinate tablets for 4 weeks. The two groups were treated with constipation symptom score and TCM symptom score. They were evaluated before and after treatment. The data recorded in the case report form were analyzed and processed by SPASS19.0 software. Results: 66 patients were analyzed. There were 35 cases in the treatment group and 31 cases in the control group. The evaluation of constipation symptoms in the two groups in clinical efficacy evaluation: the total effective rate of the treatment group was 97.14 and the total effective rate of the control group was 87.1%. By rank sum test, the total effective rate of improving constipation symptoms in the treatment group was significantly better than that in the control group. The difference between the two groups was statistically significant, which indicated that the treatment group was superior to the control group in the overall symptom treatment. In the treatment group, there were P0.05 in the four aspects of "shortness of breath", "degree of fatigue", "lack of Qi lazy speech" and "degree of anorexia". The difference was statistically significant. The treatment group can improve the symptoms of qi deficiency. The control group in the four aspects of P0.05, the difference is not statistically significant, indicating that the control group can not improve the symptoms of Qi deficiency. In terms of obtaining patient satisfaction. The satisfaction rate of the patients in the treatment group was 91.43 and that in the control group was 77.42. The difference was statistically significant by rank sum test. The treatment group can obtain the approval of the patients. The two groups in the course of treatment did not appear adverse reactions and side effects. Conclusion 1. Qizhutongbian decoction is effective in the treatment of slow transit constipation with deficiency of qi, which is effective in the treatment of constipation and the overall constipation symptoms. Related TCM symptoms and patients' satisfaction with medication were better than that of prucapride succinate tablets. 2. There were no adverse reactions and side effects in clinical application of Qizhutongbian decoction. Qizhutongbian decoction is a treatment of slow transit constipation of qi deficiency syndrome. All effective traditional Chinese medicine prescription. It is worth further popularizing and applying.
【学位授予单位】：湖南中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R256.35

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