基于复杂网络技术的针灸治疗溃疡性结肠炎的选穴研究

发布时间：2018-01-17 19:25

本文关键词：基于复杂网络技术的针灸治疗溃疡性结肠炎的选穴研究　出处：《成都中医药大学》2016年硕士论文　论文类型：学位论文

【摘要】：目的：运用复杂网络技术分析现代针灸治疗溃疡性结肠炎选穴规律并挖掘有潜力治疗溃疡性结肠炎的腧穴,以期为临床选穴和处方提供思路和参考。方法：1检索1978～2015年国内外的中医、针灸期刊所有临床医学研究文献,筛选最终纳入分析的文献,从文献中提取文献题目、使用腧穴等信息建立溃疡性结肠炎针灸处方数据库。2构建处方-腧穴二分网络,运用现代复杂网络科学技术计算处方-腧穴网络中的处方节点的度、腧穴节点的度,按照经络、部位、特定穴种类对腧穴节点进行归类。3将处方-腧穴网络映射成腧穴-腧穴有权和无权网络,对腧穴-腧穴网络节点相关特征进行分析,对边的相关特征进行分析,计算聚类系数和平均距离以分析腧穴-腧穴网的小世界特性,对网络进行社团划分,并构造该网络的k-core核心子网。结果：1处方-腧穴网分析结果：处方用穴数目大多为3到10个。共选用64个腧穴,被选用频次最多的5个穴位依次为天枢(84次)、足三里(72次)、上巨虚(57次)、关元(48次)、中脘(43次)。被选用频次最多的经脉依次为任脉、足阳明胃经、足太阳膀胱经、手阳明大肠经。就腧穴种类而言,特定穴占了57个。特定穴中募穴用穴个数少但频次很高。就部位而言,以胸腹部腧穴使用频次较高。2腧穴-腧穴网分析结果：节点度排名前十的腧穴依次为天枢、足三里、三阴交、关元、上巨虚、脾俞、中脘、公孙、内庭、肾俞；节点介数大小排名前十的腧穴依次为足三里、天枢、三阴交、上巨虚、关元、大肠俞、中脘、脾俞、内庭、大横。腧穴配伍以天枢、足三里、上巨虚、关元之间的相互配伍频次最高,使用频次最高的5组配伍依次为天枢-足三里、上巨虚-天枢、上巨虚-足三里、天枢-关元、天枢-中脘。网络聚类系数为0.846,平均路径长度为1.723。共划分为五个社团,蓝色社团以背腰部和胸腹部腧穴为主；红色社团以特定穴为主；绿色社团以足阳明胃经和手阳明大肠经腧穴为主；紫色社团以交会穴为主；黄色社团以上肢部和下肢部腧穴为主。提炼网络11-核图包含有15个节点,分别为足三里、天枢、上巨虚、大肠俞、胃俞、脾俞、三阴交、公孙、阴陵泉、关元、中脘、气海、合谷、章门。结论：溃疡性结肠炎腧穴-腧穴网络具有小世界特性,部分腧穴节点重要性强于其它腧穴。以穴位而言,天枢、足三里、上巨虚、关元、中脘、脾俞、大肠俞、肾俞、胃俞、三阴交、公孙、阴陵泉、气海、合谷、章门为核心穴位。以部位而言,取穴以胸腹部为主。以腧穴种类而言,以特定穴为主,特别是募穴。以经络而言,多选用任脉、足阳明胃经、足太阳膀胱经腧穴。腧穴配伍具有前后配穴、上下配穴、同名经配穴的规律。
[Abstract]:Objective: to analyze the rule of acupoint selection in the treatment of ulcerative colitis by using complex network technology and to excavate the potential acupoints for the treatment of ulcerative colitis. In order to provide ideas and references for clinical acupoint selection and prescriptions. Methods: 1 to search all clinical medical research literature of TCM and acupuncture journals from 1978 to 2015, and to screen the literature that was included in the analysis. The title of the literature was extracted from the literature and the information of acupoints was used to set up the database of acupuncture and moxibustion prescription for ulcerative colitis (2. 2) to construct the binary network of prescriptions and acupoints. The degree of prescription node in prescription-acupoint network and the degree of acupoint node are calculated according to meridian and position by using modern complex network science and technology. Classification of acupoints by specific types of acupoints. 3. Mapping prescription-acupoint network into acupoint-acupoint right and power networks, and analyzing the relevant characteristics of acupoint-acupoint network nodes. The correlation characteristics of the edge are analyzed, the clustering coefficient and the average distance are calculated to analyze the small-world characteristics of the acupoint and acupoint network, and the network is divided into communities. The k-core core subnet of the network was constructed. Results the results showed that the number of prescription points was mostly 3 to 10, and 64 acupoints were selected. The most frequently selected five acupoints were 84 times of Tianshu, 72 times of Zusanli, 57 times of Zhuxu and 48 times of Guanyuan). The most frequently selected meridians were Renmai, foot Yangming stomach Meridian, foot Sun bladder Meridian, hand Yangming large intestine Meridian. Specific points accounted for 57. The number of points used in specific points was small but the frequency was very high. As far as the location was concerned. The results showed that the top ten acupoints were Tianshu, Zusanli, Sanyinjiao, Guan Yuan, Shangjuxu, Peshu, Zhongwan, Gongsun and inner atrium. Shenshu; Node number of the top 10 points ranked in turn for Zusanli, Tianshu, Sanyinjiao, on Juxu, Guan Yuan, Dachang Yu, Zhongwan, spleen Yu, chambers, big transverse. Acupoints compatible with Tianshu, Zusanli, on Juxu. The five groups with the highest frequency were Tianshu Zusanli, Juxu Tianshu, Zusanli, Zushanyuan. The network clustering coefficient was 0.846, and the average path length was 1.723.There were five associations, the blue community was mainly composed of the acupoints of the back and waist and the chest and abdomen, and the average path length was 1.723.The network cluster coefficient was 0.846, and the average path length was 1.723. The red society is dominated by specific holes; The main points of green society were foot Yangming stomach Meridian and hand Yangming large intestine Meridian. Purple society is mainly rendezvous; The yellow society is mainly composed of acupoints of upper limb and lower extremity. The network 11- nuclear map contains 15 nodes, which are Zusanli, Tianshu, Shangjuxu, Dachang Yu, Weichu, spleen Yu, Sanyinjiao, Gongsun and Yinling Spring. Guanyuan, Zhongwan, Qihai, Hegu, Zhangmen. Conclusion: the network of acupoints and acupoints of ulcerative colitis has the characteristics of small world, some acupoints are more important than other acupoints. In terms of acupoints, Tianshu, Zusanli. Shangjuxu, Guan Yuan, Zhongwan, spleen Yu, Dachang Yu, Shen Yu, Wei Yu, Sanyinjiao, Gongsun, Yin Ling Spring, Qi Hai, Hegu, Zhang Men as the core acupoints. The acupoints are mainly for chest and abdomen. For the types of acupoints, the specific points are the main points, especially the acupoints. In terms of meridians, the meridians are more selected, the stomach meridian of foot yang Ming, the acupoints of bladder meridian of foot sun, and the acupoints with the combination of acupoints before and after. Upper and lower points, the same name Meridian points rule.
【学位授予单位】：成都中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R246.1

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