加减麦冬麻仁汤治疗老年功能性便秘肠燥津亏证的临床研究

发布时间：2018-01-18 04:26

本文关键词：加减麦冬麻仁汤治疗老年功能性便秘肠燥津亏证的临床研究　出处：《湖南中医药大学》2016年硕士论文　论文类型：学位论文

【摘要】：研究目的:本研究旨通过随机临床实验的方法观察加减麦冬麻仁汤对老年功能性便秘肠燥津亏证的疗效,并进一步理解方剂的配伍规律。研究方法:将60例满足纳入标准的老年功能性便秘肠燥津亏证门诊及住院患者按照完全随机的方法分为治疗组和对照组,每组例数相等,均为30例。治疗组服用加减麦冬麻仁汤,对照组服用麻仁胶囊,两组用药均为15天,治疗结束后观察疾病总疗效、中医症候疗效;在治疗过程及随访阶段持续关注治疗组与对照组用药的不良反应、安全性。结果:两药对老年功能性便秘总疗效的比较,治疗组总有效率为93.3%,对照组总有效率为83.3%,两组差异有统计学意义(P0.05),加减麦冬麻仁汤效果优于麻仁胶囊;在改善中医症候方面,加减麦冬麻仁汤和麻仁胶囊均有显著疗效(P0.01)治疗组总有效率为96.7%,对照组为73.3%,两组对中医症候总疗效差别有显著统计学差异(P0.01),加减麦冬麻仁汤显著优于麻仁胶囊;在单项中医症候积分改善的方面对比两组疗效,加减麦冬麻仁汤在改善患者大便干结、排便困难、口干少津的症状方面要显著优于麻仁胶囊(P0.01),在改善患者排便间隔时间延长、腹胀腹痛及神疲纳差方面两组疗效相当。对两组患者中能接受随访的治疗有效的(包括临床痊愈、显效及有效)随访一月,结果显示在疾病远期疗效方面加减麦冬麻仁汤优于麻仁胶囊;在用药安全性方面,两组药物用药期间均未发生不良反应。结论:加减麦冬麻仁汤对老年功能性便秘肠燥津亏证患者具有良好的临床疗效,治疗及随访过程中未见不良反应发生
[Abstract]:Objective: the aim of this study was to observe the effect of Maidong Maren decoction on senile functional constipation by random clinical trial. Study method: 60 cases of senile functional constipation were divided into treatment group and control group according to completely random method. The number of cases in each group was equal, 30 cases. The treatment group was treated with Ma-jen decoction and the control group was treated with Maren capsule for 15 days. After the treatment, the total curative effect of the disease and the curative effect of TCM symptom were observed. Results: the total effective rate of the treatment group was 93.3% compared with the total efficacy of the two drugs in the treatment of functional constipation in the elderly. The total effective rate of the control group was 83.3, the difference between the two groups was statistically significant (P 0.05), the effect of adding and subtracting Maidong Maren decoction was better than that of Maren capsule. In the aspect of improving TCM symptoms, the total effective rate was 96.7in the treatment group and 73.3% in the control group. There was significant difference between the two groups in the total curative effect of TCM symptoms. The addition and subtraction of Maoren decoction was significantly better than that of Maren capsule. In the single Chinese medicine symptom integral improvement aspect comparison two groups curative effect, add and subtracts Maidong Ma Ren decoction in the improvement patient stool dry knot, defecation difficulty, the mouth dry little Jin symptom aspect to be obviously superior to the Ma Ren capsule P0.01). The efficacy of the two groups in improving the interval of defecation, abdominal distention and anorexia was similar. The effective treatment (including clinical recovery, marked effect and effective) was followed up January for the patients in both groups. The results showed that the addition and subtraction of Maoren decoction was better than that of Maren capsule in the long term curative effect of disease. In terms of drug safety, there were no adverse reactions during the two groups. Conclusion: add and reduce Maidong Maren decoction has a good clinical effect on senile patients with functional constipation of intestinal dryness and deficiency syndrome. No adverse reactions occurred during treatment and follow-up
【学位授予单位】：湖南中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R256.35

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