术前中药联合内分泌治疗对绝经后乳腺癌患者化疗耐受性及生命质量的影响

发布时间：2018-01-19 04:00

本文关键词： 绝经乳腺癌中药内分泌化疗耐受性生命质量　出处：《辽宁中医杂志》2017年02期 　论文类型：期刊论文

【摘要】：目的:探讨术前中药联合内分泌治疗对绝经后乳腺癌患者化疗耐受性及生命质量的影响。方法:随机数字表格法将74例绝经后乳腺癌患者分为对照组与观察组各37例,术前均接受新辅助化疗治疗,此外对照组加以内分泌治疗,观察组在对照组基础上联合中药治疗,比较两组近期疗效、药物不良反应、治疗前后T淋巴细胞指标及生存质量改善情况。结果:观察组近期有效率59.46%较对照组的51.35%差异无统计学意义(P0.05)。两组内分泌治疗不良反应无显著差异(P0.05),观察组化疗恶心呕吐、骨髓抑制发生率均明显低于对照组(P0.05)。与治疗前比较,治疗2周期观察组CD3~+/CD8~+显著下降,CD4~+/CD8~+明显上升,差异有统计学意义(P0.05),且观察组治疗后CD3~+/CD8~+、CD4~+/CD8~+均明显优于对照组(P0.05)。观察组治疗后生存质量改善有效率89.19%显著高于对照组的70.27%(P0.05)。结论:术前中药联合内分泌治疗能明显减轻化疗不良反应,患者耐受性强,且能有效改善患者免疫功能,最终提高患者生存质量。
[Abstract]:Objective: to investigate the effect of preoperative Chinese medicine combined with endocrine therapy on chemotherapeutic tolerance and quality of life of postmenopausal breast cancer patients. 74 patients with postmenopausal breast cancer were randomly divided into control group and observation group. All patients received neoadjuvant chemotherapy before operation, in addition, the control group was treated with endocrine therapy, and the observation group was treated with traditional Chinese medicine on the basis of the control group. The short-term efficacy and adverse drug reactions were compared between the two groups. Results: there was no significant difference between the observation group (59.46%) and the control group (51.35%) in the improvement of T lymphocyte index and quality of life (P 0.05). There was no significant difference in adverse reactions of endocrine therapy between the two groups (P0.05). The incidence of nausea and vomiting and bone marrow suppression in the observation group was significantly lower than that in the control group (P 0.05). CD4 / / CD8 ~ increased significantly, the difference was statistically significant (P 0.05), and the observation group after treatment CD3 ~ / CD8 ~. CD _ 4 ~ / CD _ 8 ~ + was significantly better than that of control group (P 0.05). The effective rate of life quality improvement in observation group was significantly higher than that in control group (P 0.05) after treatment, and the improvement rate was significantly higher in observation group than in control group (P 0.05). Conclusion: preoperative Chinese medicine combined with endocrine therapy can significantly reduce the adverse reactions of chemotherapy. Patient tolerance, and can effectively improve the immune function of patients, and ultimately improve the quality of life of patients.
【作者单位】：济南市第三人民医院保健科;
【分类号】：R273
【正文快照】： 乳腺癌在40~60岁女性中比较常见,是导致女性死亡的高危疾病之一。目前临床治疗乳腺癌以化疗、内分泌干预等综合治疗为主,其中新辅助化疗+手术应用较多,术前通过新辅助化疗能有效减少肿瘤分期,缩小病灶,提高保乳术几率[1]。近年来临床发现激素依赖型乳腺癌患者越来越多,对绝经

【相似文献】