基于FibroScan评价祛痰活血颗粒治疗非酒精性脂肪性肝病痰瘀互结证临床疗效

发布时间：2018-01-19 18:43

本文关键词： 祛痰活血颗粒非酒精性脂肪性肝病 FibroScan　出处：《西南医科大学》2017年硕士论文　论文类型：学位论文

【摘要】：目的:通过观察祛痰活血颗粒治疗非酒精性脂肪性肝病(NAFLD)痰瘀互结证型病人的腹围和体重指数,肝功和血脂,FibroScan检测结果和腹部B超以及症状的变化,评价祛痰活血颗粒治疗非酒精性脂肪性肝病痰瘀互结证临床疗效。方法:将84例痰瘀互结证NAFLD病人用随机表法分成治疗组和对照组,两组各42例,治疗组病人给予口服祛痰活血颗粒,对照组病人给予口服多烯磷脂酰胆碱胶囊,治疗3个月,分别比较两组病人治疗前后的腹围和体重指数,肝功和血脂,FibroScan检测结果和腹部B超以及中医症状的变化。结果:(1)两组病人的年龄、男女性别数比较无差别(P0.05),两组可比较。两组病人的血常规、肾功能、尿常规、大便常规、心电图等安全指标未见异常。(2)两组病人的腹围和体重指数治疗前后对比有差异(P0.01),具有统计学意义;肝功和血脂治疗前后对比有差异(P0.01),具有统计学意义;FibroScan检测结果以及中医症状治疗前后对比有差异(P0.01),具有统计学意义。治疗后两组病人的腹围和体重指数,肝功和血脂,FibroScan检测结果和中医症状组间比较没有差别(P0.05)。(3)两组病人治疗前后查腹部B超提示肝脏脂肪变程度改变不显著(P0.05),治疗后组间比较肝脂肪变差别不明显(P0.05)。结论:(1)祛痰活血颗粒治疗NAFLD痰瘀互结证病人能降低病人的腹围和体重指数,使肝功、血脂恢复,降低FibroScan检测值和缓解中医症状。(2)祛痰活血颗粒治疗NAFLD痰瘀互结证对腹部彩超影像学改变不大,对FibroScan检测值有较大影响,FibroScan检测更有利用于NAFLD患者随访管理。(3)祛痰活血颗粒治疗NAFLD痰瘀互结证总体的疗效较多烯磷脂酰胆碱胶囊组优越。(4)祛痰活血颗粒治疗NAFLD痰瘀互结证疗效明显,服用方便,安全性好。
[Abstract]:Objective: to observe the abdominal circumference, body mass index (BMI), liver function and blood lipid of patients with non-alcoholic fatty liver disease (NAF LDD) treated by Quphan Huoxue granule. The results of FibroScan and the changes of abdominal B ultrasound and symptoms. Objective: to evaluate the clinical efficacy of Quphan Huoxue granule in treating non-alcoholic fatty liver disease with phlegm and blood stasis syndrome. Methods: 84 cases of NAFLD with phlegm and blood stasis syndrome were randomly divided into treatment group (n = 42) and control group (n = 42). The patients in the treatment group were given oral dispel phlegm and blood circulation granule, and the patients in the control group were treated with polyene phosphatidylcholine capsule for 3 months. The abdominal circumference and body mass index, liver function and blood lipid of the two groups were compared before and after treatment. FibroScan test results, abdominal B ultrasound and changes of TCM symptoms. Results there was no difference in age, sex between male and female patients in the two groups (P0.05). The blood routine, renal function, urine routine and stool routine were compared between the two groups. There was no significant difference in abdominal circumference and body mass index between the two groups before and after treatment (P 0.01). There was significant difference between liver function and blood lipid before and after treatment (P 0.01). The results of FibroScan and the comparison of TCM symptoms before and after treatment had statistical significance. After treatment, the abdominal circumference and body mass index, liver function and blood lipid of the two groups were significantly different. There was no difference between the results of FibroScan examination and the group of TCM symptoms. (P0.05. 3) the abdominal ultrasonography before and after treatment showed that there was no significant change in the degree of hepatic steatosis in the two groups (. P0.05). After treatment, there was no significant difference in liver fat change between the two groups. Conclusion: Quphlegm Huoxue granule can reduce the abdominal circumference and body mass index of patients with NAFLD syndrome of phlegm and blood stasis and make liver function. Blood lipids recovery, reduce FibroScan detection value and alleviate the symptoms of traditional Chinese medicine. 2) Quphlegm Huoxue granule treatment of NAFLD phlegm and blood stasis syndromes has little change in abdominal color ultrasound imaging. It has great influence on the detection value of FibroScan. FibroScan detection is more favorable for NAFLD patients follow up management. 3) Quphlegm Huoxue granule treatment of NAFLD phlegm and blood stasis syndromes overall curative effect is superior to that of multiene phosphatidylcholine capsule group. 4) expelling phlegm and activating blood granule in treating NAFLD syndrome of phlegm and blood stasis is obvious. Easy to take and safe.
【学位授予单位】：西南医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R259

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