射干麻黄汤治疗儿童哮喘发作期临床疗效及对血清细胞因子、骨桥蛋白及TIMP-1水平的影响

发布时间：2018-01-19 23:01

本文关键词： 射干麻黄汤儿童哮喘细胞因子骨桥蛋白基质金属蛋白酶的组织抑制剂-　出处：《中国实验方剂学杂志》2017年20期 　论文类型：期刊论文

【摘要】：目的:探讨射干麻黄汤治疗儿童哮喘发作期临床疗效及对血清白细胞介素-6(interleukin-6,IL-6),白细胞介素-8(interleukin-8,IL-8),肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)和超敏C反应蛋白(high sensitive-C reaction protein,hsCRP),骨桥蛋白(osteopontin,OPN)及基质金属蛋白酶的组织抑制剂-1(tissue inhibitor of metalloproteinases-1,TIMP-1)水平的影响。方法:选取哮喘急性发作期患儿161例,随机分为治疗组(81例),对照组(80例)。对照组采用西医常规疗法,治疗组予射干麻黄汤进行治疗,清水煎煮,每日1剂,治疗后对哮喘患儿临床疗效,血清IL-6,IL-8,TNF-α,hs-CRP,OPN及TIMP-1水平进行比较,并观察两组患儿不良反应。结果:治疗组患者总有效率为93.83%,对照组为81.25%,治疗组优于对照组(P0.05);与治疗前比较,治疗后两组患儿血清IL-6,IL-8,TNF-α,hs-CRP水平均明显降低(P0.05),且治疗组血清IL-6,IL-8,TNF-α,hs-CRP水平明显低于对照组(P0.05);与治疗前比较,治疗后两组患儿OPN与TIMP-1水平均有明显降低(P0.05);治疗组OPN与TIMP-1表达明显低于对照组(P0.05);与治疗前比较,治疗后两组中医证候积分均有明显改善(P0.05);治疗组中医证候积分低于对照组(P0.05);两组不良反应比较差异无统计学意义。结论:射干麻黄汤治疗哮喘发作期患儿临床疗效显著,作用机制可能与减少患者细胞因子IL-6,IL-8,TNF-α和hs-CRP水平,降低OPN与TIMP-1表达有关。
[Abstract]:Objective: to investigate the clinical effect of Sheganmahuang decoction in the treatment of childhood asthma attack and the serum interleukin-6 interleukin-6 (IL-6). Interleukin-8 Interleukin-8 Interleukin-8 (IL-8), tumor necrosis factor- 伪, tumor necrosis factor- 伪 (TNF- 伪). TNF- 伪 and high sensitive-C reaction protein hsCRP). Osteopontin. OPN) and tissue inhibitor of metalloproteinases-1, a tissue inhibitor of matrix metalloproteinases. Methods: 161 children with acute asthma were randomly divided into treatment group (81 cases) and control group (80 cases). The treatment group was treated with Sheganmahuang decoction, clear water decoction, 1 dose per day, after the treatment of children with asthma clinical efficacy, serum IL-6 + IL-8 TNF- 伪 TNF- 伪 hs-CRP. The levels of OPN and TIMP-1 were compared and the adverse reactions of the two groups were observed. Results: the total effective rate was 93.83 in the treatment group and 81.25% in the control group. The treatment group was superior to the control group (P 0.05). Compared with before treatment, the serum levels of IL-6, IL-8, TNF- 伪 and hs-CRP in the two groups were significantly lower than those before treatment, and the serum levels of IL-6 and IL-8 in the treatment group were significantly lower than those in the control group. The level of TNF- 伪 hs-CRP was significantly lower than that of control group (P 0.05). Compared with before treatment, the levels of OPN and TIMP-1 in the two groups were significantly lower than those before treatment (P 0.05). The expression of OPN and TIMP-1 in the treatment group was significantly lower than that in the control group (P 0.05). Compared with before treatment, the scores of TCM syndromes in the two groups were significantly improved after treatment (P 0.05). The score of TCM syndrome in the treatment group was lower than that in the control group (P 0.05). There was no significant difference between the two groups in adverse reactions. Conclusion: Sheganmahuang decoction has a significant clinical effect in the treatment of children with asthma attack, and the mechanism may be related to the reduction of IL-6 IL-8. The levels of TNF- 伪 and hs-CRP were related to the decrease of OPN and TIMP-1 expression.
【作者单位】：武汉大学附属同仁医院;
【基金】：武汉市卫生和计划生育委员会临床医学科研项目(WX14C17)
【分类号】：R272
【正文快照】： [网络出版地址]http://kns.cnki.net/kcms/detail/11.3495.R.20170731.1039.048.html[网络出版时间]2017-07-31 10:39儿童哮喘是儿科常见的呼吸系统疾病,临床上主要以反复咳喘、胸闷、呼吸困难等为主要症状[1]。该病好发于4~5岁儿童,我国0~14岁儿童支气管哮喘发病率约为0.11%~

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