三黄膏治疗局部软组织感染临床疗效观察

发布时间：2018-01-20 03:41

本文关键词： 三黄膏外敷软组织感染谷氨酸-丙酮酸氨基转移酶天门冬氨酸氨基转移酶尿素氮肌酐　出处：《中国实验方剂学杂志》2017年20期 　论文类型：期刊论文

【摘要】：目的:观察三黄膏外敷治疗体表软组织感染的临床疗效,探讨其作用机制。方法:120例软组织感染患者随机分为三黄膏大剂量组、三黄膏小剂量组和对照组;观察治疗前后感染部位局部肿胀、红斑、疼痛、硬结、温度、脓疱或溃疡的好转情况,检测治疗前及治疗后第1,3,5,7天血常规、尿常规、肝肾功能指标谷氨酸-丙酮酸氨基转移酶(ALT),天门冬氨酸氨基转移酶(AST),尿素氮(BUN),肌酐(Cr)变化。结果:三黄膏大剂量组病程(6.93±2.74)d,小剂量组(7.75±2.93)d,对照(鱼石脂软膏)组(8.77±2.82)d,与对照组治疗后比较,三黄膏外敷明显缩短了病程(P0.05);三黄膏使患者一般状况综合评分明显下降(P0.05),能促进局部肿块消散,红肿消退,减轻疼痛,降低局部温度,促进脓疱及溃疡愈合;治疗后第1,3天,三黄膏大、小剂量组血常规、尿常规、肝肾功能(ALT,AST,BUN,Cr)恢复正常的人数高于对照组(P0.05);治疗后第5,7天,各检验结果均基本恢复正常;治疗期间未见明显不良反应。结论:三黄膏对体表软组织感染具有确切治疗作用,可缩短病程,临床安全性高,值得推广。
[Abstract]:Objective: to observe the clinical efficacy and mechanism of Sanhuang ointment in treating surface soft tissue infection. Methods: 120 patients with soft tissue infection were randomly divided into Sanhuang ointment high dose group. Sanhuang ointment small dose group and control group; The local swelling, erythema, pain, rigidity, temperature, pustules or ulcers were observed before and after treatment. Blood routine and urine routine were detected before and after treatment. Liver and kidney function indexes: glutamic acid-pyruvate aminotransferase (alt), aspartate aminotransferase (ASTT), urea nitrogen (bun). Results: the course of disease was 6.93 卤2.74 days in the high dose group and 7.75 卤2.93 days in the low dose group. Compared with the control group, the course of disease was significantly shortened by external application of Sanhuang ointment, compared with the control group (8.77 卤2.82 days). Sanhuang ointment can obviously decrease the patients' general state comprehensive score (P0.05), promote the local mass dissipate, redness and swelling fade, relieve the pain, reduce the local temperature, and promote the healing of pustules and ulcers. On the 1st day after treatment, the number of patients with normal blood routine, urine routine and liver and kidney function were higher than that of control group (P 0.05). On the 5th day after treatment, the results of each test returned to normal basically. Conclusion: Sanhuang ointment has definite therapeutic effect on body surface soft tissue infection, can shorten the course of disease, has high clinical safety, and is worth popularizing.
【作者单位】：甘肃中医药大学;甘肃省中药药理与毒理学重点实验室;甘肃中医药大学附属医院;
【基金】：甘肃省中医管理局科研项目(GZK-2011-42) 甘肃省中药药理与毒理学重点实验室开放基金项目(ZDSYS-KJ-2016-007)
【分类号】：R269
【正文快照】： [网络出版地址]http://kns.cnki.net/kcms/detail/11.3495.R.20170731.1037.044.html[网络出版时间]2017-07-31 10:37体表软组织感染是临床常见病、多发病,是病原体入侵、滞留与繁殖所引起的急性炎症反应,目前缺乏特异性的有效治疗手段和方法[1-2]。西医主要采用局部消毒、理

【相似文献】