灯盏细辛注射液与灯盏花素注射液治疗缺血性中风急性期临床疗效间接比较的Meta分析

发布时间：2018-01-20 11:42

本文关键词： 灯盏细辛注射液灯盏花素注射液缺血性中风 Meta分析间接比较　出处：《中国中药杂志》2017年06期 　论文类型：期刊论文

【摘要】：系统比较灯盏细辛注射液(DZXI)和灯盏花素注射液(DZSI)治疗缺血性中风急性期临床有效性和安全性。采用Meta分析和间接比较法(ITC),以复方丹参注射液(FDI)为中介,查找相关临床随机对照试验(RCT),纳入DZXI或DZSI对比FDI治疗缺血性中风急性期的临床RCTs文献进行间接Meta分析。结果共纳入文献39篇,包括4 180个病例。Meta分析结果显示:DZXI和DZSI在治疗缺血性中风急性期的疗效均优于FDI;通过间接比较,DZSI总有效率高于DZXI,具有显著统计学差异[OR=0.634,95%CI=(0.432,0.928),P0.000 01];而在改善神经功能缺损方面无明显统计学差异[MD=-1.19,95%CI=(-3.57,1.19),P=0.953];安全性方面,所纳入的研究中DZXI不良反应率为1.14%,主要不良反应为头胀、发热、畏寒等;DZSI无明显不良反应。目前有限的证据表明灯盏花素注射液总有效率和安全性高于灯盏细辛注射液;但由于所纳入的RCT质量不高,全面评估二者的临床作用特点仍需高质量的临床试验。
[Abstract]:The efficacy and safety of Erigeron breviscapus injection (DZXI) and breviscapine injection (DZSI) in the treatment of acute ischemic stroke were systematically compared. Meta analysis and indirect comparison were used to compare the efficacy and safety of DZXI and breviscapine injection in the treatment of acute ischemic stroke. . The RCTs of compound salvia miltiorrhiza injection (FDI) were investigated in a randomized controlled trial (RCT). Indirect Meta analysis was carried out in clinical RCTs literature involving DZXI or DZSI in the treatment of acute ischemic stroke compared with FDI. Results 39 articles were included. The results of Meta-analysis including 4 180 cases showed that both DZSI and DZXI were more effective than FDI in the treatment of acute ischemic stroke. The total effective rate of DZSI was significantly higher than that of DZXI by indirect comparison. [ORX 0.634 + 95CIQ 0.432U 0.928 P0.00001], but there was no significant difference in improving the nerve function defect. [MD-1.19 ~ 95 ~ (-3.57) ~ (1.19) / P ~ (0.953); In terms of safety, the adverse reaction rate of DZXI in the study was 1.14. The main adverse reactions were head distension, fever, chills and so on. There was no obvious adverse reaction in DZSI. The limited evidence showed that the total effective rate and safety of breviscapine injection was higher than that of Erigeron breviscapus injection. But because the quality of RCT included is not high, high quality clinical trials are needed to evaluate the clinical characteristics of both.
【作者单位】：昆明理工大学生命科学与技术学院;云南省第二人民医院老年病科;
【基金】：国家自然科学基金项目(81460631) 昆明理工大学药物代谢平台建设项目(14078184)
【分类号】：R255.2
【正文快照】： 中风是一种常见脑血管疾病,分为缺血性中风和出血性中风,大多数中风(约占85%)属于缺血性中风[1]。缺血性中风的发病机制主要是由于动脉粥样硬化等形成血栓,使血管被完全或部分堵塞所致。缺血性中风具有发病率、致残率、死亡率高的特点[2]。灯盏细辛又名灯盏花,系菊科飞蓬属植

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