2型糖尿病中医证型与临床生化指标的关系

发布时间：2018-01-21 01:36

本文关键词： 型糖尿病中医辨证分型临床生化指标　出处：《南京中医药大学学报》2017年05期 　论文类型：期刊论文

【摘要】：目的探讨2型糖尿病中医证型与临床生化指标的关系,为2型糖尿病中医辨证提供客观依据。方法收集187例符合标准的2型糖尿病病例,按阴虚热盛、脾虚痰瘀、气阴两虚、气虚血瘀辨证分型,同时以40例同期健康体检者做对照。分析不同证型与年龄、体质量指数(BMI)、糖代谢、脂代谢、超敏C反应蛋白(hs-CRP)、胰岛素抵抗指数(HOMA-IR)、血清胰岛素(FINS)等的关系。结果与正常对照组比较,(1)阴虚热盛组BMI显著下降(P0.01),脾虚痰瘀型BMI显著增加(P0.01);(2)糖尿病组TC、TG、LDL指标均升高(P0.05),HDL指标下降(P0.05);(3)糖尿病组FPG、HOMA-IR、HbA1c、hs-CRP水平均升高(P0.05~0.01);FINS指标除阴虚热盛组外其余3组均下降与正常对照组比较有统计学意义(P0.05~0.01)。结论 2型糖尿病各中医证型与脂代谢、糖代谢、体质量指数、胰岛素抵抗指数等存在相关性,通过其关系的研究,将有助于糖尿病中医辨证的客观化。
[Abstract]:Objective to explore the relationship between TCM syndromes and clinical biochemical indexes of type 2 diabetes mellitus and to provide objective basis for TCM syndrome differentiation of type 2 diabetes mellitus. Methods 187 cases of type 2 diabetes mellitus were collected according to yin deficiency and heat. Spleen deficiency and phlegm stasis, deficiency of qi and yin, deficiency of qi and blood stasis were classified according to syndrome differentiation. At the same time, 40 cases of healthy physical examination were used as control. Different syndromes and age, body mass index (BMI), glucose metabolism and lipid metabolism were analyzed. The relationship between the hypersensitive C-reactive protein hs-CRP, the insulin resistance index (HOMA-IRN) and the serum insulin FINS were compared with those in the normal control group. (1) in Yin-deficiency and Reisheng group, BMI decreased significantly (P 0.01), and BMI in spleen deficiency and phlegm stasis increased significantly (P 0.01). (2) in the diabetic group, the TCU TGN LDL index was increased and the HDL index was decreased (P0.05). (3) the levels of HbA1chs-CRP in FPGsHOMA-IRN in diabetic group were all higher than that in control group (P0.05). The FINS indexes in the other three groups except Yin deficiency and Heat Sheng group were significantly lower than those in the normal control group. Conclusion the TCM syndromes and lipid metabolism and glucose metabolism of type 2 diabetes mellitus were significantly lower than those of the normal control group. Body mass index (BMI) and insulin resistance index (IR) are correlated.
【作者单位】：新疆医科大学第一附属医院;
【基金】：新疆维吾尔自治区自然科学基金(2016D01C310)
【分类号】：R259
【正文快照】： 糖尿病是胰岛素作用缺陷或分泌障碍引起的以血糖水平升高,可伴有血脂异常等为特征的代谢性疾病。目前在我国20岁以上的成年人糖尿病患病率为9.7%,其中90%~95%为2型糖尿病患者[1]。由于糖尿病病程冗长,常致心、脑、肾、眼、神经等多脏器损害[2],已成为第三位严重威胁人类生命健

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