补肾安胎方治疗肾虚型早期先兆流产的临床观察

发布时间：2018-01-21 02:53

本文关键词： 早期先兆流产补肾安胎方血清E_2 临床研究　出处：《南京中医药大学》2017年硕士论文　论文类型：学位论文

【摘要】：目的:通过本项研究,证明补肾安胎方治疗肾虚型先兆流产安全有效。并证实血清E2预测早期先兆流产妊娠结局比血清P、β-HCG更有参考价值。方法:将肾虚型早期先兆流产患者随机分为中西药组和西药组各30例,西药组肌注黄体酮,40mg/次,1次/日;中西药组肌注黄体酮同时口服中药汤剂补肾安胎方。至少治疗14天,见胎心或胎儿基本成形后方可停药。观察两组患者治疗前后的临床症状、实验室检查结果,进行统计分析。结果:1)中西药组临床综合疗效与西药组比较,总有效率为93.3%vs 83.3%,有显著差异(P0.05)。2)两组治疗前与治疗后中医症状积分比较均有明显差异(P0.05)。中西药组与西药组中医症状积分的治疗前后的差值相比,有显著性差异(P0.05)。3)两组B超所见胎心、胎儿成形情况,治疗后与治疗前相比,都有显著差异(P0.05),两组间治疗后的B超所见胎心及胎儿成形比较无显著差异(P0.05)。4)两组血清E2、P、β-HCG均明显增高,与治疗前相比有显著性差异(P0.05);两组治疗后的血清E2、β-HCG与治疗前E2、β-HCG的差值相比,有显著差异(P0.05),P差值比较无明显差异(P0.05)。但中西药组的差值略大于西药组。5)孕酮偏低的先兆流产患者中,最终保胎失败组与保胎成功组相比较,治疗前的E2值有显著差异(P0.05);P、β-HCG值无明显差异(P0.05)。结论:补肾安胎方治疗肾虚型早期先兆流产安全有效,明显减轻患者的临床症状,改善血清性激素水平,促进胚胎发育。血清E2水平评价临床疗效及预测早期先兆流产妊娠结局均比血清P、β-HCG更有参考价值。
[Abstract]:Objective: to prove the safety and effectiveness of Bushen Antii recipe in the treatment of threatened abortion of kidney deficiency type, and to confirm that serum E2 is more effective than serum P in predicting pregnancy outcome of early threatened abortion. Methods: patients with early threatened abortion of kidney deficiency type were randomly divided into Chinese medicine group and western medicine group (30 cases each). 40 mg / day of progesterone was injected intramuscularly in the western medicine group. Chinese and western medicine group intramuscular injection of progesterone and oral Chinese medicine decoction Bushen Anti prescription. At least 14 days treatment, see fetal heart or fetal basic shaping before and after treatment before and after treatment before and after the observation of the two groups of patients' clinical symptoms. Results compared with the western medicine group, the total effective rate of the Chinese and western medicine group was 93. 3 vs 83.3%. There was significant difference between the two groups before and after the treatment of TCM symptom scores were significantly different (P0.05). The difference of TCM symptom score between Chinese medicine group and western medicine group was compared before and after treatment. There were significant differences in fetal heart and fetal shape between the two groups after treatment and before treatment (P 0.05). There was no significant difference in fetal heart and fetal shape between the two groups after treatment (P0.05. 4) the serum levels of E2P and 尾 -HCG in the two groups were significantly higher than those in the control group. There was significant difference between before treatment and before treatment (P 0.05). The difference of serum E _ 2, 尾 -HCG between the two groups after treatment was significantly different from that before treatment (P 0.05). There was no significant difference in P difference between the two groups. However, the difference between the Chinese and western medicine group was slightly larger than that in the western medicine group. 5) in the threatened abortion patients with low progesterone, the final failure group was compared with the successful group. There was significant difference in E _ 2 value before treatment (P 0.05). Conclusion: Bushen Antii prescription is safe and effective in the treatment of early threatened abortion of kidney deficiency type. It can obviously alleviate the clinical symptoms of patients and improve the level of serum sex hormone. Serum E _ 2 level is more valuable than serum P, 尾 -HCG in evaluating clinical efficacy and predicting pregnancy outcome of early threatened abortion.
【学位授予单位】：南京中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R271.9

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