越鞠丸合乌贝散加减治疗气郁痰阻型反流性食管炎的临床观察

发布时间：2018-01-21 18:11

本文关键词： 越鞠丸合乌贝散加减反流性食管炎气郁痰阻临床观察　出处：《山东中医药大学》2016年硕士论文　论文类型：学位论文

【摘要】：目的:本次研究以气郁痰阻型反流性食管炎作为临床疗效的观察点,比较越鞠丸合乌贝散加减与西药泮托拉唑钠肠溶片(泰美尼克)联合多潘立酮(吗丁啉)对此证型患者症状的改善情况,从而为反流性食管炎的中医临床研究提供客观依据。方法:按照随机、对照的研究方法,将60例符合纳入标准的反流性食管炎的患者随机分为两组,其中试验组30例,对照组30例。试验组以越鞠丸合乌贝散加减(中药汤剂每日300ml分早晚两次温服)治疗;对照组以泰美尼克(40mg,一日一次,晨起空腹口服),吗丁啉(10mg,一日三次,早中晚三餐前半小时口服)治疗,疗程均为两个月。以临床症状积分为疗效评价指标,观察两组治疗前后各症状积分及相关指标变化情况,并采用SPSS19.0统计软件进行数据分析。结果:试验组临床痊愈2例,显效12例,有效15例,无效1例,总有效率为96.67%;对照组临床痊愈0例,显效6例,有效19例,无效5例,总有效率为83.33%;两组治疗后临床综合疗效经秩和检验分析得:P=0.01(P0.05),差异具有统计学意义,提示试验组疗效优于对照组。结论:越鞠丸合乌贝散加减是治疗气郁痰阻型反流性食管炎的安全有效方剂,本方在改善患者临床症状方面及消除食管粘膜炎症方面均不低于西药对照组,值得在临床中进一步研究及推广应用。
[Abstract]:Objective: to observe the clinical effect of reflux esophagitis with Qi stagnation and phlegm obstruction. To compare the improvement of symptoms between Yueju Pill and Wubei Powder and western medicine pam Tora sodium enteric-coated tablet (Tamenick) combined with domperidone (morpholine). Methods: according to the randomized and controlled study, 60 patients with reflux esophagitis were randomly divided into two groups. There were 30 cases in the test group and 30 cases in the control group. The control group was treated with 40 mg of Titanic, once in the morning, once in the morning, 10 mg in the morning, 3 times in 1st, half an hour before the meal. The course of treatment was two months. Taking the clinical symptom score as the therapeutic evaluation index, the changes of each symptom score and related indexes before and after treatment were observed in the two groups. Results: in the trial group, 2 cases were cured, 12 cases were effective, 15 cases were effective, 1 case was ineffective, and the total effective rate was 96.677.Results: 2 cases were cured, 12 cases were effective, 1 case was ineffective, and the total effective rate was 96.67%. In the control group, there were 0 cases of clinical cure, 6 cases of remarkable effect, 19 cases of effective and 5 cases of ineffective. The total effective rate was 83.33; The clinical comprehensive curative effect of two groups after treatment was analyzed by rank sum test, and the difference was statistically significant. Conclusion: Yueju pill combined with Wubei powder is a safe and effective prescription for treating reflux esophagitis of qi stagnation and phlegm obstruction type. In improving the clinical symptoms of patients and eliminating the inflammation of esophagus mucosa, this prescription is not lower than the control group of western medicine, which is worthy of further study and application in clinical practice.
【学位授予单位】：山东中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259

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