清热化湿和解少阳法治疗热痹型成人STILL病的临床观察

发布时间：2018-01-22 10:26

本文关键词： 清热化湿和解少阳法来氟米特洛索洛芬钠片热痹成人Still病　出处：《黑龙江中医药大学》2017年硕士论文　论文类型：学位论文

【摘要】：目的:通过分析清热化湿和解少阳法对热痹型成人Still病的临床效果,评价清热化湿和解少阳法在热痹型成人Still病中的有效性,为医治成人Still病提供新的中医治疗思维。方法:将30例符合本课题研究方案的热痹型纳入者,随机分为治疗组15例,口服中药自拟方150ml,日两次口服;联合洛索洛芬钠片60mg,日三次口服;来氟米特20mg,日一次口服。对照组15例,予洛索洛芬钠片60mg,日三次口服;来氟米特20mg,日一次口服。两组周期均是12周,并对其进行临床观察。治疗前,通过计算两组受试者的性别、年龄、病程等基本信息,无统计学意义,具有可比性。通过软件分析治疗前后两组患者中医证候积分及生化指标WBC、ESR、CPR、SF等变化,进而评判两种方案的临床有效率。结果:1.主要中医症状比较:治疗组在改善患者发热、皮疹、咽痛、口渴、关节疼痛、关节肿胀、关节发热及肌肉酸软等方面优于对照组,差异具有统计学意义(p0.05)。2.生化指标比较:治疗组在降低WBC、ESR、CPR、SF等方面结果显示,治疗组优于对照组,差异具有统计学意义(P0.05)。3.两组总有效率比较:治疗组总有效率为93.33%;对照组总有效率为60.00%。治疗组优于对照组,差异具有统计学意义(P0.05)。结论:1.试验结果表明,通过清热化湿和解少阳法,以法立方明显改善患者发热、皮疹、咽痛、口渴、关节疼痛、关节肿胀、关节发热及肌肉酸软等中医症状,同时临床疗效确切。2.试验结果表明,通过清热化湿和解少阳法,以法立方也能明显降低患者的白细胞计数、血沉、C反应蛋白、血清铁蛋白水平等生化指标。
[Abstract]:Objective: to evaluate the effectiveness of the method of clearing away heat and removing dampness and reducing yang in the treatment of Still disease of adults with heat arthralgia by analyzing the clinical effect of the method of clearing away heat and removing dampness and reducing yang. In order to treat adult Still's disease, 30 cases of heat arthralgia were randomly divided into treatment group (n = 15) and oral Chinese medicine prescription (150 ml). Twice a day; In combination with losuprofen sodium tablets 60 mg, oral three times a day; Leflunomide 20 mg, once a day, control group 15 cases, Losoprofen sodium tablets 60 mg, oral three times a day; Leflunomide 20mg, once a day. The two groups of cycle is 12 weeks, and clinical observation. Before treatment, by calculating the sex, age, course of disease and other basic information, there is no statistical significance. Through the software analysis of the two groups of patients before and after treatment of TCM syndromes integral and biochemical indicators such as the changes of ESRP CPRSF and so on. Results: 1. Comparison of main TCM symptoms: the treatment group improved fever, rash, pharynx, thirst, joint pain, joint swelling. The joint fever and muscle weakness were better than the control group, the difference was statistically significant (P 0.05). Comparison of biochemical indexes: the treatment group in the reduction of WBCU ESR-CPR. The results of SF and other aspects showed that the treatment group was superior to the control group, the difference was statistically significant (P 0.05) .3.The total effective rate of the two groups was 93.33; The total effective rate of the control group was 60.00.The treatment group was superior to the control group, the difference was statistically significant (P 0.05). The symptoms of fever, rash, pharynx, thirst, joint pain, joint swelling, joint fever and muscle weakness were obviously improved by French cube. By the method of clearing away heat and removing dampness and eliminating yang, the white blood cell count, erythrocyte sedimentation rate C reactive protein, serum ferritin level and other biochemical indexes were also significantly decreased.
【学位授予单位】：黑龙江中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R259

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