润肠通便方治疗慢性功能性便秘（阴虚燥热证）的临床研究

发布时间：2018-01-22 12:39

本文关键词： 润肠通便方功能性便秘阴虚燥热证临床分析　出处：《湖北中医药大学》2016年硕士论文　论文类型：学位论文

【摘要】：目的本文旨在观察润肠通便方治疗功能性便秘(阴虚燥热型)的临床疗效、安全性及较治疗同种证型对比成药的优势,并从理论及临床疗效两方面论证该方的应用价值。方法1.观察对象为湖北省中医院2014.6-2015.12消化内科门诊病人60例。随机分为两组,每组30人,分别治疗组跟对照组,治疗组予润肠通便方,对照组予滋阴润肠口服液,疗程4周,观察治疗前,治疗后4周疗效。治疗组与对照组年龄均为18-65岁,两组患者性别、年龄、病程、总有效率、中医证候总积分等方面的比较无明显差异,具有可比性(P0.05)。2.治疗组润肠通便方组成:当归10g,厚朴10g,火麻仁15g,苦杏仁10g,芦荟15g,肉苁蓉15g,生首乌10g,熟地黄12g,郁李仁10g,枳实15g。上述药物用水煎服,每次150ml,一天两次。对照组滋阴润肠口服液组成:生地黄。3.统计学方法:数据应用SPSS17.0统计软件进行分析,计数资料中独立/配对的二组二分类资料比较,独立的多组二分类资料用卡方检验,有序的多组多分类资料用秩和检验,对配对比较的资料应采用符号秩和检验(signed-rank test)多个样本比较的秩和检验可用Kruskal-Wallis法。符合正态分布的计量资料用t检验来推断差异发生的概率,从而判定两个平均数的差异是否显著[14]。P值小于0.05就认为结果有显著性差异。P值大于0.05就认为结果无显著性差异。结果治疗组与对照组总有效率分别为90.00%,76.67%,差异无统计学意义,治疗组能够够促进大便的排出,提高排便的频率,减轻排便的相关不适症状,且效果优于对照组。结论润肠通便方能够促进大便的排出,提高排便的频率,减轻排便的相关不适症状,对慢性功能性便秘(阴虚燥热型)确有疗效,无明显副作用,安全性良好,值得进一步研究和推广。
[Abstract]:Objective to observe the clinical efficacy, safety and advantages of Runchang Tongbian recipe in treating functional constipation (Yin deficiency, dryness and heat). And from the theoretical and clinical efficacy of the application of the prescription to demonstrate the value. 1. Observe the object of Hubei Hospital of traditional Chinese Medicine, 2014.6-2015.2014.6-2015.12 outpatients in the Department of Digestive Medicine, 60 patients were randomly divided into two groups. 2. Each group of 30 people, respectively treatment group and control group, the treatment group was given Runchang Tongbian recipe, the control group was given Ziyin Runchang oral liquid, the course of treatment for 4 weeks, observation before treatment. The treatment group and the control group are 18-65 years old, the two groups of patients gender, age, course of disease, total effective rate, TCM syndromes total score, there is no significant difference between the two groups. In the treatment group, the composition of Runchang and defecation prescription: Angelica sinensis 10g, Magnolia officinalis 10g, Huomaoren 15g, bitter almond 10g, aloe 15g, Cistanche 15g. Shengshouwu 10g, cooked Rehmannia 12g, Tuliren 10g, Fructus Aurantii 15g. Two times a day. Control group Ziyin Runchang oral liquid composition: Rehmannia glutinosa. 3. Statistical method: the data were analyzed by SPSS17.0 software. Two groups of independent / paired data were compared in the counting data. The independent multi-group and two-class data were tested by chi-square test, and the ordered multi-group multi-classification data were tested by rank sum test. The paired data should be matched by signed rank sum test (signed-rank test). The rank sum test for multiple sample comparisons can be performed by Kruskal-Wallis method. The t test is used to infer the probability of occurrence of the difference in the econometric data according to the normal distribution. To determine whether the difference between the two averages is significant. [14] .P < 0. 05. The results were significantly different. P > 0. 05. Results the total effective rate of treatment group and control group was 90.00%, respectively. 76.67, the difference is not statistically significant, the treatment group can promote the excretion of stool, improve the frequency of defecation, reduce the symptoms of defecation related discomfort. And the effect is better than the control group. Conclusion Runchang Tongbian prescription can promote excretion of defecation, increase defecation frequency, alleviate the related discomfort symptoms of defecation, and have effect on chronic functional constipation (Yin deficiency dry-heat type). No obvious side effects, good safety, worthy of further study and promotion.
【学位授予单位】：湖北中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R256.35

【相似文献】