补肾调肝法治疗高龄肝郁肾虚型膝骨性关节炎的临床研究

发布时间：2018-01-23 10:22

本文关键词： 膝骨性关节炎高龄补肾调肝肝郁肾虚　出处：《广州中医药大学》2017年硕士论文　论文类型：学位论文

【摘要】：目的:探讨补肾调肝法对高龄肝郁肾虚型膝骨性关节炎的临床疗效,为中医药治疗膝骨性关节炎提供新的思路和方法。方法:根据中医辨证从本院门诊选择60名符合纳入标准的膝骨性关节炎患者,按照随机数字表法以1:1的比例随机分成服用补肾调肝方的中药组(试验组)及口服塞来昔布的西药组(对照组)。两组患者均不使用其他同类中药或者西药治疗。记录治疗前、治疗30天后两组患者中医症状总积分、膝关节肿胀、VAS评分、膝关节活动度、膝关节Lysholm评分及SDS抑郁评分的变化。对临床疗效进行评价,观察并及时记录治疗过程中出现的严重不良反应。搜集并整理数据,采用SPSS20.0进行统计学分析。结果:1.治疗前,试验组及对照组患者一般资料:膝关节VAS评分、膝关节活动度、肿胀、中医症状总积分、膝关节Lysholm评分及SDS抑郁评分比较无统计学意义(P0.05)。2.治疗30天后,试验组及对照组患者治疗前后组内VAS评分、关节活动度、肿胀、中医症状总积分、膝关节Lysholm评分及SDS抑郁评分比较均有统计学意义(P0.05),两组患者均取得了较好的临床疗效。3.治疗30天后,试验组及对照组患者VAS评分、关节活动度、肿胀、中医症状总积分及膝关节Lysholm评分比较均无统计学意义(P0.05);SDS抑郁评分比较差异显著(P0.05)。4.治疗30天后,试验组及对照组患者治疗前后VAS评分差值、关节活动度差值、肿胀评分差值、中医症状总积分差值及膝关节Lysholm评分差值比较均无统计学意义(P0.05);SDS抑郁评分差值比较差异显著(P0.05)。5.治疗30天后,试验组和对照组临床疗效做比较差异无统计学意义(P0.05);两组总有效率比较无显著性差异(P0.05)。结论:补肾调肝方治疗高龄肝郁肾虚型膝骨性关节炎疗效满意,能减轻患者疼痛,改善膝关节活动,且未出现严重药物不良反应,值得临床推广。
[Abstract]:Objective: To investigate the clinical effect of invigorating kidney and regulating liver in aged liver and kidney deficiency type knee osteoarthritis, to provide new ideas and methods for the treatment of osteoarthritis of knee osteoarthritis. Methods: according to TCM syndrome differentiation of traditional Chinese medicine from the hospital outpatient 60 patients met the inclusion criteria of knee osteoarthritis patients, Chinese medicine group according to the random number table method with the ratio of 1:1 were randomly divided into taking bushentiaogan Fang (experimental group) and oral celecoxib western medicine group (control group). Two groups of patients were not using other similar Chinese medicine or western medicine treatment. Recorded before treatment, 30 days after treatment in two groups of TCM symptoms total score, VAS score, knee swelling. The activity of knee joint and knee joint change scores of Lysholm and SDS depression scores. To evaluate the clinical curative effect, observation and timely recording of serious adverse reactions during the treatment. The collected data were analyzed by SPSS20.0 statistical Histological analysis. Results: 1. before treatment, the experimental group and the control group of patients with general information: VAS knee score, knee joint activity and swelling, the TCM symptoms total score, Lysholm knee score and the SDS score was not statistically significant (P0.05.2.) 30 days after treatment, the experimental group and the control group of patients before and after treatment group in the VAS score, joint activity and swelling, the TCM symptoms total score, Lysholm knee score and SDS score were statistically significant (P0.05), two patients achieved good clinical efficacy of.3. after 30 days of treatment, the experimental group and the control group of patients with VAS score, joint activity and swelling, traditional Chinese medicine symptoms integral and Lysholm score were not statistically significant (P0.05); SDS depression score difference was significant (P0.05.4.) 30 days after treatment, the experimental group and the control group before and after treatment in patients with VAS score difference, joint activity difference, swelling rating The difference, difference of total score of clinical symptoms and Lysholm score difference was not statistically significant (P0.05); SDS depression score difference was significant difference (P0.05.5.) 30 days after treatment, the test group and the control group to compare the clinical efficacy difference was not statistically significant (P0.05); the total efficiency of two groups had no significant difference. (P0.05). Conclusion: the curative effect in the treatment of elderly liver and kidney deficiency type knee osteoarthritis with adjustable liver kidney, can reduce the pain of patients, improve the knee joint activities, and no severe adverse reaction, worthy of promotion.

【学位授予单位】：广州中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R274.9

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