溃结灵Ⅳ号对大肠湿热型UC活动期患者血清HIF-1α和粪便LF影响的临床观察

发布时间：2018-01-25 13:46

  本文关键词： 溃疡性结肠炎 溃结灵Ⅳ号 保留灌肠 低氧诱导因子 乳铁蛋白　出处：《黑龙江中医药大学》2017年硕士论文　论文类型：学位论文

【摘要】：溃疡性结肠炎(ulcerative colitis,UC)是一种慢性非特异性肠道疾病,具体致病因素不明确。目前医学界普遍认为UC的发病是由家族遗传、免疫调节、环境等各种因素共同导致的。主要以腹痛、腹泻、粘液脓血便为主。病变部位主要局限在结直肠的粘膜层和粘膜下层,弥漫性分布,主要集中在直肠、乙状结肠为主。UC在欧美远高于发病率国内,但近些年在我国也有明显的递增趋势。在治疗方面,西医主要以5-氨基水杨酸、糖皮质激素、免疫抑制剂为主,最近几年出现了一类新的药物——生物制剂,能提供更加有效的靶向治疗。鉴于西药长期使用带来的副作用以及治疗成本的居高不下,中医药治疗UC另辟蹊径,不仅在UC症状缓解方面取得了显著的疗效,而且为患者节约了客观的经济支出,发挥了中药便捷、廉价、有效的优势。这也为我们进一步研究探索中医中药治疗UC带来了信心。目的:探讨溃结灵Ⅳ号对大肠湿热型UC活动期患者的疗效。方法:将符合大肠湿热型活动期UC诊断标准的30例患者随机分成治疗组(15例)和对照组(15例)。治疗组和对照组分别采用溃结灵Ⅳ号和美沙拉嗪保留灌肠,早晚各一次,一个疗程为7天,连续4疗程。观察治疗组与对照组中患者血清HIF-1 α和粪便LF含量变化水平,以此指标评估溃结灵Ⅳ号和美沙拉嗪疗效对比,为临床使用结灵Ⅳ号提供可靠依据。结果:治疗前后治疗组、对照组的血清HIF-1α和粪便LF含量均有明显降低。其中,治疗组血清HIF-1 α治疗前(85.65 ± 11.16)ng/L,治疗后(41.52± 9.57)ng/L,变化率(44.13± 12.79)ng/L,P0.05。对照组血清HIF-1α治疗前(86.84±12.05)ng/L,治疗后(52.27 ±10.19)ng/L,变化率(34.57±11.68)ng/L,P0.05。治疗组粪便LF治疗前(94.93 ± 17.41)ng/L,治疗后(12.21± 2.07)ng/L,变化率(82.71±16.65)ng/L,P0.05。对照组粪便 LF 治疗前(92.87± 16.15)ng/L,治疗后(12.69± 3.44)ng/L,变化率(80.17±14.55)ng/L,P0.05。治疗组的Sutherland、肠镜评分与对照组均有明显改善。结论:1.溃结灵Ⅳ号对大肠湿热型UC活动期患者的疗效显著。2.溃结灵Ⅳ号可使大肠湿热型UC活动期患者的血清HIF-1 α和粪便LF明显降低。
[Abstract]:Ulcerative colitis (UCC) is a chronic nonspecific intestinal disease. The specific pathogenic factors are not clear. At present, medical circles generally believe that UC is caused by family heredity, immune regulation, environment and other factors, mainly by abdominal pain, diarrhea. Mucus abscess mainly. The lesion is mainly located in the mucous layer and submucous layer of the colorectal, diffuse distribution, mainly concentrated in the rectum, sigmoid colon mainly in Europe and the United States is much higher than the incidence of domestic. But in recent years, there is an obvious increasing trend in our country. In the treatment, Western medicine is mainly 5-aminosalicylic acid, glucocorticoid, immunosuppressant. In recent years, a new class of medicine-biological agents have appeared. Can provide more effective targeted treatment. In view of the long-term use of Western medicine side effects and high cost of treatment, Chinese medicine treatment UC is a new way. Not only in the relief of UC symptoms achieved a significant effect, but also for patients to save the objective economic expenditure, played a convenient and cheap Chinese medicine. The effective advantage. This also brings confidence for us to further study and explore Chinese medicine to treat UC. Objective: to explore the curative effect of Kuijieling 鈪，

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