清金化痰汤治疗肺癌合并轻度肺部感染的临床观察

发布时间：2018-01-26 14:33

本文关键词： 清金化痰汤肺癌轻度肺部感染临床观察　出处：《广州中医药大学》2017年硕士论文　论文类型：学位论文

【摘要】：目的:观察评价清金化痰汤治疗肺癌合并轻度肺部感染的临床疗效,试图为肺癌合并轻度肺部感染寻求安全有效、经济方便的综合疗法,改善患者生活质量。方法:采用随机、对照原则,以非小细胞肺癌患者54例作为研究对象,通过观察中医症候积分以及KPS评分,WBC、NEU%、PCT、CRP、ESR等指标的变化,评价清金化痰汤治疗肺癌合并轻度肺部感染的疗效,为其推广应用提供临床依据。结果:1.两组对肺部感染的总疗效:治疗组的总有效率为96.2%,对照组的有效率为81.6%,两组治疗方案在疗效方面均有效,治疗组痊愈率为48.1%,无效为3.8%,对照组痊愈率为3.8%,无效率为18.4%,经秩和检验,2=-3.869,P=0,P0.05,故两组在疗效方面的差异有统计学意义,治疗组肺部感染的疗效优于对照组。2.两组对痰热郁肺证患者中医症状都有改善作用:(1)清金化痰汤组中医症候疗效改善情况为,痊愈率为33.3%,无效为0,有效率为100%,对照组有效率为85.2%,痊愈率为0,两组疗效经秩和检验,差异具有统计学意义,治疗组中医症候的改善优于对照组。(2)经治疗后两组均能改善患者的痰量、痰色、痰质、气喘、口干、发热、舌脉。经组间比较,在改善各个中医症状方面,治疗组优于对照组,(p0.05),具有统计学意义。在症状总积分改善上,治疗组优于对照组,(p0.05),具有统计学意义。3.两组均能降低白细胞、中性粒百分比,降钙素原、C反应蛋白、血沉等感染指标,在降低感染指标方面,清金化痰汤组降低幅度更大,(p0.05),具有统计学意义。4.两组均能提高肺癌合并轻度肺部感染患者的KPS评分(p0.05),具有统计学意义;两组组间比较差异无统计学意义(p0.05)。5.在治疗过程中,两组均无不良事件发生。结论:清金化痰汤能改善肺癌合并轻度肺部感染患者咳嗽咳痰、气喘、口干、发热等症状,减少患者肺部Up音,改善舌脉,降低其感染指标,提高KPS评分,具有明显疗效,且治疗过程中无不良事件发生,故清金化痰汤治疗肺癌合并轻度肺部感染有效且安全,早期应用可防止肺部感染进一步进展,从而对肺癌合并肺部感染的治疗也是有利的。
[Abstract]:Objective: to observe and evaluate the clinical effect of Qingjin Huatan decoction (QJHuatang) in the treatment of lung cancer with mild pulmonary infection, and to seek safe, effective, economical and convenient comprehensive therapy for lung cancer complicated with mild pulmonary infection. Methods: 54 patients with non-small cell lung cancer (NSCLC) were studied on the basis of randomization and control principle. The TCM symptom score and KPS score were observed. To evaluate the efficacy of Qingjin Huatan decoction in the treatment of lung cancer with mild pulmonary infection. Results the total curative effect of the two groups on pulmonary infection: the total effective rate of the treatment group was 96. 2 and the effective rate of the control group was 81.6%. The cure rate was 48.1 in the treatment group, 3.8in the invalid group, 3.8 in the control group, and 18.4in the control group. The difference between the two groups in the curative effect was statistically significant. The therapeutic effect of pulmonary infection in the treatment group is better than that in the control group. 2. The two groups have improved the symptoms of traditional Chinese medicine in the patients with phlegm-heat stagnation lung syndrome. The curative effect of Qingjin Huatan decoction group is improved. The cure rate is 33.3%. The ineffective rate was 0, the effective rate was 100 and the control group was 85.2 percent and the cure rate was 0. The difference between the two groups was statistically significant by rank sum test. The improvement of TCM symptoms in the treatment group was better than that in the control group.) after treatment, both groups could improve the amount of phlegm, the color of phlegm, the quality of phlegm, asthma, dry mouth, fever and tongue pulse. In improving the symptoms of traditional Chinese medicine, the treatment group is better than the control group (P 0.05), with statistical significance. In the improvement of the total symptom score, the treatment group is better than the control group (P 0.05). Both groups can reduce leukocyte, neutrophil percentage, calcitonin proto-C-reactive protein, erythrocyte sedimentation rate and other infection indicators, in terms of reducing the infection index, Qingjinhuatan decoction group decreased more. The KPS score of lung cancer patients with mild pulmonary infection was significantly higher than that of control group (P 0.05). There was no significant difference between the two groups. There were no adverse events in the two groups. Conclusion: Qingjin Huatan decoction can improve cough and expectoration in patients with lung cancer and mild pulmonary infection. Asthma, dry mouth, fever and other symptoms, reduce the patients' lung up sound, improve the tongue vein, reduce its infection index, improve the KPS score, have obvious curative effect, and there are no adverse events in the course of treatment. So Qingjin Huatan decoction is effective and safe in the treatment of lung cancer with mild pulmonary infection, and early application can prevent further progress of lung infection, which is also beneficial to the treatment of lung cancer with pulmonary infection.
【学位授予单位】：广州中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R273

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