肾虚血瘀型青春期多囊卵巢综合征中药干预临床研究

发布时间：2018-01-28 04:00

本文关键词： 多囊卵巢综合征青春期肾虚血瘀型中药干预　出处：《新疆医科大学》2017年硕士论文　论文类型：学位论文

【摘要】：目的:通过中药干预临床实验研究,观察肾虚血瘀型青春期多囊卵巢综合征患者中医临床症状、性激素水平、糖代谢指标、卵泡数目、体重指数在干预前后的变化,探讨中药联合达英-35治疗该病的优势,为中西医结合治疗肾虚血瘀型青春期多囊卵巢综合征提供临床依据。方法:选择2014年12月至2016年12月期间乌鲁木齐市中医院门诊及病房诊断为青春期多囊卵巢综合征的患者,收集符合本实验标准的患者80例,对照组、试验组各40例。治疗组中药“补肾化瘀调经汤”+达英-35治疗,对照组单纯口服达英-35治疗,两组连续服用3个月。观察两组治疗后的临床疗效并进行用药安全性评估。结果:1.两组均能有效改善患者的中医临床症状,治疗后治疗组较对照组改善明显,差异有统计学意义(P0.05);2.两组均能降低患者血清LH、T及LH/FSH比值,差异有统计学意义(P0.05,治疗后治疗组较对照组下降明显,差异有统计学意义(P0.05);两组患者治疗前后血清E _2、FSH无统计学意义(P0.05);3.两组患者治疗前后FPG、FINS及HOMA-IR无统计学意义(P0.05);4.两组均能降低患者BMI及痤疮评分,差异有统计学意义(P0.05),治疗后治疗组较对照组下降明显,差异有统计学意义(P0.05);5.两组均能减少患者双侧卵泡数目,差异有统计学意义(P0.05);治疗后治疗组较对照组减少更为明显(P0.05)。结论:中药“补肾化瘀调经汤联合达英-35”治疗可以改善肾虚血瘀的中医临床症状,规律月经周期,降低血清LH、T及LH/FSH值,降低BMI,改善面部痤疮,减少双侧卵泡数目,提示中西医结合治疗有良好的疗效。
[Abstract]:Objective: to observe the clinical symptoms, sex hormone level, glucose metabolism index and follicle number of the patients with polycystic ovary syndrome (PCOS) of kidney deficiency and blood stasis type. The change of body mass index (BMI) before and after intervention was discussed in order to explore the advantages of traditional Chinese medicine combined with Dain-35 in the treatment of the disease. To provide the clinical basis for the treatment of adolescent polycystic ovary syndrome of kidney deficiency and blood stasis type by the combination of traditional Chinese and western medicine. Methods:. Patients with polycystic ovary syndrome (PCOS) diagnosed in outpatient and ward of Urumqi traditional Chinese Medicine Hospital from December 2014 to December 2016 were selected. 80 patients in accordance with the standard of this experiment, the control group, 40 cases in each group. The treatment group "Bushen Huayu Tiaojing decoction" Daying -35 treatment group, the control group only oral Daying -35 treatment. The two groups were taken continuously for 3 months. The clinical efficacy of the two groups was observed and the safety of the drug was evaluated. Results the two groups could effectively improve the clinical symptoms of traditional Chinese medicine (TCM). After treatment, the treatment group was significantly improved than the control group, and the difference was statistically significant (P 0.05). 2. Both groups can reduce the ratio of serum LHH T and LH/FSH, the difference is statistically significant (P 0.05). After treatment, the treatment group is significantly lower than the control group. The difference was statistically significant (P 0.05). Before and after treatment, there was no significant difference in serum E _ 2H _ 2 FSH between the two groups (P 0.05). 3. Before and after treatment, there was no significant difference in FG fins and HOMA-IR between the two groups (P 0.05). 4. The BMI and acne score of the two groups were significantly lower than that of the control group, and the difference was statistically significant (P 0.05). 5. both groups could reduce the number of bilateral follicles, the difference was statistically significant (P 0.05). Conclusion: the treatment group can improve the clinical symptoms of kidney deficiency and blood stasis and regular menstrual cycle with the combination of "Bushen Huayu Tiaojing decoction" and "Da Ying -35". It is suggested that the combination of traditional Chinese and western medicine has a good effect on reducing serum LHT and LH/FSH, decreasing BMIs, improving facial acne and reducing the number of bilateral follicles.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R271.9

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