益气养阴活血方治疗早期糖尿病心肌病的临床观察

发布时间：2018-01-30 01:50

本文关键词： 糖尿病心肌病早期益气养阴活血方　出处：《中国中西医结合杂志》2017年05期 　论文类型：期刊论文

【摘要】：目的观察益气养阴活血方对早期糖尿病心肌病患者的临床疗效。方法将80例早期糖尿病心肌病患者随机分为对照组和治疗组,每组40例。两组均采取基础降糖治疗,对照组口服阿托伐他汀钙片;治疗组在对照组的基础上加用益气养阴活血方治疗。两组均治疗12周。观察两组患者治疗前后空腹血糖(fasting blood glucose,FBG)、糖化血红蛋白A1c(glycosylated hemoglobin A1c,HbA1c)、TC、TG、LDL-C、HDL-C、餐后2 h血糖(2 h postprandial blood glucose,2 h PG)、左室射血分数(left ventricular ejection fraction,LVEF)、E峰/A峰比值(E/A)及中医证候疗效变化情况。结果与本组治疗前比较,治疗后两组FBG、2 h PG、HbA1c、TC、TG、LDL-C均降低(P0.05),治疗组HDL-C升高(P0.05),两组LVEF、E/A值均提高(P0.05);与对照组比较,治疗组治疗后FBG、2 h PG、HbA1c、TC、TG、LDL-C均明显降低,HDL-C升高,LVEF、E/A值升高明显,差异均有统计学意义(P0.05)。治疗组中医证候疗效为90.0%(36/40),优于对照组[67.5%(27/40)],差异有统计学意义(χ~2=4.781,P=0.028)。结论益气养阴活血方在早期糖尿病心肌病的治疗方面,具有辅助降糖、协同调脂、改善心室舒张功能、改善中医证候疗效的作用。
[Abstract]:Objective to observe the clinical effect of Yiqi Yangyin Huoxue recipe on early diabetic cardiomyopathy. Methods 80 patients with early diabetic cardiomyopathy were randomly divided into control group and treatment group. 40 cases in each group were treated with basic hypoglycemic therapy, and the control group were treated with Atto vastatin calcium tablets. The treatment group was treated with Yiqi Yangyin Huoxue recipe on the basis of the control group. Both groups were treated for 12 weeks. The fasting blood glucose was observed before and after treatment. Glycosylated hemoglobin A1C hemoglobin A1C HbA1C HbA1C, TBC TGG, LDL-C, HDL-C, HbA1C, HbA1C, HbA1C, HbA1C. 2 h postprandial glucose and 2 h postprandial blood glucose 2 h PG2). Left ventricular ejection fractionation (LVEF). The changes of E / A ratio and TCM syndromes were compared with those before treatment. LDL-C decreased P0.05A, HDL-C increased P0.05A in treatment group, and the E / A value of LVEFV increased P0.05a in both groups. Compared with the control group, in the treatment group, the level of HDL-C increased and the E / A value of LVEFG increased significantly in the treatment group. The curative effect of TCM syndrome in the treatment group was 90.036 / 40, which was better than that in the control group. [The difference was statistically significant (蠂 ~ (2 +) 2.781) (P 0.028). Conclusion Yiqi Yangyin Huoxue recipe is effective in the treatment of early diabetic cardiomyopathy. It can improve ventricular diastolic function and improve the curative effect of TCM syndrome.
【作者单位】：河北省保定市第一中医院内分泌科;解放军252医院中医科;河北师范大学体育学院;
【分类号】：R259
【正文快照】： 糖尿病心肌病(diabetic cardiomyopathy,DCM)是指特发于糖尿病患者、除外冠心病、高血压病等疾病、以心室舒张或收缩功能障碍及心脏结构改变为主要表现、最终可进展为心力衰竭的一种疾病,组织病理表现为心肌细胞肥厚、变性,微血管病变伴血管再生障碍及血管周围和(或)心肌间质

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