疏肝滋肾法对女性骨关节病患者激素水平及炎症因子的影响

发布时间：2018-01-31 07:07

本文关键词： 疏肝滋肾法女性骨关节病 E T TNF-α IL-β　出处：《辽宁中医杂志》2017年06期 　论文类型：期刊论文

【摘要】：目的:探讨疏肝滋肾法对女性骨关节病患者激素水平及炎症因子的影响。方法:将76例女性骨关节病患者分为两组,每组38例。对照组采用西医常规治疗。研究组采用疏肝滋肾法治疗。于治疗前后对比两组症状评分、视觉模拟评分法(VAS)评分、关节骨性关节炎严重性指数(ISOA)评分及血清雌激素(E_2)、孕酮(T)、肿瘤坏死因子α(TNF-α)、白细胞介素1β(IL-1β)的变化。结果:研究组的疗效显著优于对照组,差异有统计学意义(P0.05);两组治疗后症状评分、VAS评分、ISOA评分均显著降低(P0.05);治疗后,研究组症状评分、VAS评分、ISOA评分显著低于对照组,差异有统计学意义(P0.05);两组治疗后E_2、T显著升高,TNF-α、IL-1β显著降低(P0.05);治疗后,研究组E_2、T显著高于对照组,TNF-α、IL-1β显著低于对照组,差异有统计学意义(P0.05)。结论:疏肝滋肾法对女性骨关节病的疗效确切,能显著改善患者临床症状,减轻关节疼痛,提高雌激素水平,减轻炎症反应。
[Abstract]:Objective: to investigate the effect of the method of soothing the liver and nourishing the kidney on the hormone level and inflammatory factors in female patients with osteoarthropathy. Methods: 76 female patients with osteoarthropathy were divided into two groups. 38 cases in each group. The control group was treated with routine western medicine. The study group was treated with the method of soothing the liver and nourishing the kidney. The scores of symptoms and visual analogue scores were compared before and after treatment. The severity index of osteoarthritis (ISOAA) and serum estradiol (E), progesterone (TX), tumor necrosis factor 伪 (TNF- 伪). Results: the therapeutic effect of the study group was significantly better than that of the control group (P 0.05). After treatment, the symptom scores and VAS scores and ISOA scores in both groups decreased significantly (P 0.05). After treatment, the scores of VAS and ISOA in the study group were significantly lower than those in the control group (P 0.05). After treatment, E2T in both groups was significantly increased and TNF- 伪 -IL-1 尾 significantly decreased (P 0.05). After treatment, the level of E2T in the study group was significantly higher than that in the control group, and the level of IL-1 尾 in the study group was significantly lower than that in the control group. The difference was statistically significant (P 0.05). Conclusion: the method of soothing the liver and nourishing the kidney is effective in the treatment of female osteoarthropathy, which can significantly improve the clinical symptoms of the patients, relieve joint pain and improve the level of estrogen. Reduce inflammation.
【作者单位】：唐山市丰润区第二人民医院中医科;唐山市丰润区人民医院;唐山市中医院;唐山市丰南区中医院;
【基金】：河北省中医药管理局科研计划项目(2014273)
【分类号】：R274.9
【正文快照】： 骨关节病又称为退行性骨关节病,好发于绝经后的妇女,临床主要症状包括关节疼痛、畸形、肿胀,严重影响生存质量。骨关节病是由多种因素作用促使关节软骨细胞分级,基质合成降低,关节软骨不断软化、退变、脱落,骨质逐步硬化,形成骨赘及骨下囊肿。西医治疗以保守治疗为主,虽可减轻

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