215例湿热型强直性脊柱炎中药治疗数据挖掘及关联规则研究

发布时间：2018-02-01 00:06

本文关键词： 强直性脊柱炎湿热型关联规则数据挖掘免疫炎症　出处：《中国中西医结合杂志》2017年11期 　论文类型：期刊论文

【摘要】：目的应用数据挖掘技术和关联规则分析安徽中医药大学第一附属医院风湿科中医论治湿热型强直性脊柱炎(AS)用药对患者免疫炎症及超氧化物歧化酶(SOD)指标的影响。方法基于数据挖掘技术,对安徽中医药大学第一附属医院风湿科215例2012年6月—2015年6月湿热型AS住院患者的病历资料进行回顾性研究。结合复杂网络技术挖掘其核心处方,并采用SPSS Clementine 12.0软件Aprior模块分析中药对免疫炎症及SOD指标的影响。结果 (1)对其中药处方进行分析,核心用药为:薏苡仁、陈皮、山药、茯苓、泽泻、蒲公英、白花蛇舌草、桃仁、红花、丹参、宧莶草、威灵仙、杜仲、狗脊、甘草。核心药物使用均在50%以上,其中以健脾药使用最多,药物以归脾、胃、肾经为主。(2)在关联规则最小置信度设为60%,最小支持度设为20%条件下提取值与指标关联较高的药对,山药配伍独活、黄柏分别与C3、C4关联度较高(置信度为85.19%,93.33%),与茯苓配伍与hs-CRP关联度高(置信度为78.10%);茯苓配伍知母与IgA、IgG关联度较高(置信度为83.33%,91.67%);黄柏配伍桃仁与ESR关联度较高(置信度为85.71%);宧莶草配伍蒲公英、独活分别与SOD、WBC关联度较高(置信度为85.71%,75.93%)。外用药芙蓉膏、消瘀接骨散与ESR、hs-CRP、SOD关联度较高。结论根据各用药的比例分析,本院风湿科治疗湿热型AS以从脾论治为主,兼顾肝肾,配伍祛风除湿、清热解毒、活血化瘀等药物的配方原则;并且中药内服及外用,与免疫炎症及SOD指标关联性高。
[Abstract]:Objective to analyze the application of data mining technology and association rules in the treatment of patients with immune inflammation and superoxide dismutase (SOD) by using traditional Chinese medicine (TCM) in the Department of Rheumatology of the first affiliated Hospital of Anhui University of traditional Chinese Medicine for treatment of hygrothermal ankylosing spondylitis (ASA). Methods based on data mining technology. A retrospective study was conducted on the medical records of 215 cases of hygrothermal type as inpatients from June 2012 to June 2015 in the Department of Rheumatology, the first affiliated Hospital of Anhui University of traditional Chinese Medicine. Heart prescription. SPSS Clementine 12.0 software Aprior module was used to analyze the effect of Chinese medicine on immune inflammation and SOD index. Results 1) the prescription of traditional Chinese medicine was analyzed. The core drugs are: Coix seed, Chen Pei, yam, Poria cocos, Alismatics, Dandelion, White Flower, Peach Kernel, Safflower, Salvia miltiorrhiza, Sesbeckiae, Weiling Immortals, Eucommia, Dog Ridge. Glycyrrhiza uralensis. The use of core drugs are above 50%, in which spleen medicine is the most, drugs to spleen, stomach, kidney meridian mainly. 2) the minimum confidence in association rules is set to 60%. When the minimum support degree was 20%, the extraction value was higher than the index, the Chinese yam compatibility was unique, and the correlation degree between Cortex Phellodendri and C _ 3N _ 4 was higher (confidence was 85.19 ~ 93.3333). The compatibility with Poria cocos had high correlation with hs-CRP (the confidence was 78.10%). There was a high correlation between the compatibility of Poria cocos and IgA- IgG (the confidence was 83.33). The correlation between Phellodendron chinensis and ESR was high (confidence was 85.71%). The relationship between Siegesbeckiae and dandelion was high (confidence was 85.71%). Furong ointment, Xiaoyu Jiegu Powder and ESR-hs-CRP were used as external medicine. Conclusion according to the analysis of the proportion of different drugs, the treatment of damp-heat type as by rheumatology in our hospital is mainly based on spleen treatment, taking into account liver and kidney, combined with dispelling wind and removing dampness, clearing heat and detoxification. Principles of prescription of drugs such as promoting blood circulation and removing blood stasis; And Chinese medicine oral and external use, and immune inflammation and SOD indicators are highly correlated.
【作者单位】：安徽中医药大学研究生院;安徽中医药大学第一附属医院风湿科;
【基金】：国家中医药重点学科中医痹病学建设项目(No.国中医药发[2009]30号) 国家临床重点专科中医风湿病科建设项目(No.财社[2013]239号) 国家自然基金青年项目(No.81403388) 安徽省重点实验室建设项目(No.1306c083035) 安徽省科技攻关项目(No.1604a0802085) 安徽省自然基金项目(No.1508085QH159)
【分类号】：R259
【正文快照】： 强直性脊柱炎(ankylosing spondylitis,AS)属于风湿病范畴,其病变主要累及骶髂关节,引起脊柱强直和纤维化,造成弯腰、行走活动不利,并有不同程度的多器官损害[1]。AS病程长、反复发作、致残率高,其发病机制尚不明确且尚不能根治。现代医学治疗主要应用非甾体抗炎药、生物制剂

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