和阳散结法治疗桥本氏病的临床研究

发布时间：2018-02-02 23:58

本文关键词： 桥本氏病和阳散结法中医药疗法　出处：《山东中医药大学》2016年硕士论文　论文类型：学位论文

【摘要】：目的:观察和阳散结法治疗桥本氏病的临床疗效,并初步探讨该治法及其对应方药治疗桥本氏病的作用机理。方法:将符合本研究的60例患者随机分为两组,对照组30例予常规左甲状腺素钠片治疗,治疗组在常规左甲状腺素钠片治疗的基础上,加用以和阳散结为法所拟的柴桂消瘿汤,两组疗程均为8周。分别评价治疗前后患者临床症状及体征、中医证候总积分、FT3、FT4、TSH、TPOAb、TGAb等指标的变化,以及不良反应和依从性等情况。结果:经统计分析,治疗前两组性别、年龄、病程等均具有可比性(P0.05),治疗后治疗组总有效率为86.7%,对照组总有效率为73.3%,且两组有差异(P0.05)。组间比较治疗组中医证候总积分改善情况优于对照组(P0.01)。与治疗前比较,两组治疗后FT3、FT4、TSH水平均有显著改善(P0.01);治疗后组间比较无明显差异(P0.05)。与治疗前相比,两组TPOAb、TGAb水平均有降低,治疗组TPOAb、TGAb降低幅度比对照组大(P0.01);治疗后组间比较有明显差异(P0.01)。两组临床用药安全性高,均未出现不良反应。结论:和阳散结法治疗桥本氏病患者,能显著改善患者的临床表现,降低甲状腺抗体水平,未见明显不良反应,其作用机制值得进一步探讨。
[Abstract]:Objective: to observe the clinical effect of Heyang Sanjie method in treating Hashimoto's disease, and to explore the mechanism of the treatment and its corresponding prescription for Hashimoto's disease. Methods: 60 patients with Hashimoto's disease were randomly divided into two groups. The control group (30 cases) was treated with routine levothyroxine sodium tablets, and the treatment group (30 cases) was treated with routine levothyroxine sodium tablet, and the treatment group was treated with Chaigui Xiaoying decoction (Zai Gui Xiaoying decoction). The course of treatment in both groups was 8 weeks. The changes of clinical symptoms and signs, total integral of TCM syndromes and TPOAbAbTGAb were evaluated before and after treatment. Results: according to the statistical analysis, the sex, age and course of disease of the two groups were comparable before treatment (P 0.05). The total effective rate of the treatment group was 86.7%. The total effective rate of the control group was 73.3%, and there was a difference between the two groups. The improvement of the total integral of TCM syndromes in the treatment group was better than that in the control group (P 0.01). After treatment, the levels of TSH in FT3 and FT4 were significantly improved in both groups (P 0.01). After treatment, there was no significant difference between the two groups (P 0.05). Compared with before treatment, the levels of TPO Ab TGAb in the two groups were decreased, and the TPOAb in the treatment group was lower than that in the control group. The decrease of TGAb was greater than that of control group (P 0.01). There was significant difference between the two groups after treatment P0.010.The safety of the two groups was high and there was no adverse reaction. Conclusion: the treatment of Hashimoto's disease with Heyang Sanjie method can significantly improve the clinical manifestations of the patients. The mechanism of decreasing thyroid antibody level without obvious adverse reaction is worth further study.
【学位授予单位】：山东中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259

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