乌蛇止痒方治疗艾滋病相关瘙痒性丘疹性皮疹临床研究
本文关键词： 乌蛇止痒方 艾滋病相关瘙痒性丘疹性皮疹 脾虚湿蕴证 临床症状体征 皮肤生活质量 出处：《时珍国医国药》2017年05期 论文类型：期刊论文
【摘要】：目的观察乌蛇止痒方对艾滋病相关瘙痒性丘疹性皮疹脾虚湿蕴证患者临床症状体征的改善。方法 45例HIVPPE脾虚湿蕴证患者随机分入治疗组及对照组。治疗组23例,对照组22例。最终完成治疗者41例,其中治疗组21例,对照组20例;治疗组给予乌蛇止痒方(乌梢蛇、苍术、淮山药、鸡内金、泽泻、白芍、当归、茯苓、白鲜皮、苦参、防风、黄芩、甘草)口服;对照组给予抗组胺药物氯雷他定。分别在治疗3周、8周后比较治疗前后两组患者临床表现量化评分、中医症状体征、皮肤生活质量指数和血常规等指标变化。结果两组患者治疗8周后,治疗组皮损改善优于对照组,临床疗效明显好于对照组,两组有效率比较具有明显差异(P0.01);治疗3周后,与对照组相比,治疗组皮肤症状体征就已经有所改善(P0.05);治疗8周后,治疗组与对照组相比,结节、丘疹、苔癣样变、瘙痒症状体征改善明显(P0.01)。治疗3周后,治疗组乏力、纳呆、腹胀有所改善(P0.05);治疗8周后,治疗组与对照组比较,乏力、纳呆均有明显改善(P0.01)。两组患者经过8周治疗后,治疗组皮肤生活质量明显提高,两组比较具有显著性差异(P0.01)。结论乌蛇止痒方能够有效治疗HIV-PPE脾虚湿蕴证患者,改善其临床症状和体征,提高患者生活质量。
[Abstract]:Objective to observe the improvement of Wushizhi prescription on clinical symptoms and signs of AIDS related pruritus with spleen deficiency and dampness accumulation syndrome. 45 patients with HIVPPE spleen deficiency and dampness accumulation syndrome were randomly divided into the treatment group and the control group, 23 cases in the treatment group. There were 22 cases in the control group and 41 cases in the final treatment group, including 21 cases in the treatment group and 20 cases in the control group. The treatment group was treated by oral administration of Wushen Zhiyang recipe (Wutiao snake, Atractylodes Atractylodes, Huai yam, Chicken Neijin, Rhizoma Alismatis, Radix Paeoniae Alba, Radix angelicae Sinensis, Poria cocos, White fresh skin, Sophora flavescens, Fangfeng, Scutell@@. The control group was given the antihistamine loratadine. After 3 weeks and 8 weeks of treatment, the clinical symptoms and signs of the two groups were compared before and after treatment. Results after 8 weeks of treatment, the improvement of skin lesions in the treatment group was better than that in the control group, and the clinical effect was better than that in the control group. There was significant difference in the effective rate between the two groups (P 0.01). After 3 weeks of treatment, compared with the control group, the skin symptoms and signs of the treatment group have been improved P0.05; After 8 weeks of treatment, the treatment group compared with the control group, nodules, papules, lichen like changes, pruritus symptoms and signs significantly improved P0.01.After 3 weeks of treatment, the treatment group was weak and incapacitated. Abdominal distension improved P0.05; After 8 weeks of treatment, compared with the control group, the patients in the treatment group had significant improvement in both fatigue and incapacity. After 8 weeks of treatment, the skin quality of life in the treatment group was significantly improved. Conclusion Wushi Zhiyang prescription can effectively treat HIV-PPE patients with spleen deficiency and dampness accumulation, improve its clinical symptoms and signs, and improve the quality of life of the patients.
【作者单位】： 桂林市中医医院;广西中医药大学附属瑞康医院;
【基金】：广西壮族自治区卫生厅中医药科技专项(No.GZLC14-43)
【分类号】：R259
【正文快照】： 艾滋病相关瘙痒性丘疹性皮疹(human immunodeficiency vi-rus pruritic papular eruption,HIV-PPE,简称艾滋病相关性痒疹)是HIV/AIDS患者中最常见的炎症性皮肤病之一。患者往往主诉瘙痒比较严重,伴随的结节和丘疹不易消退,常规治疗药物和方法效果不明显,总体疗效欠佳,治疗较为
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