基于线粒体融合分裂探析脾胃失调与重症肌无力的关系

发布时间：2018-02-04 08:02

本文关键词： 重症肌无力线粒体融合分裂　出处：《中华中医药学刊》2017年01期 　论文类型：期刊论文

【摘要】：重症肌无力为难治性疾病,属中医"痿证"范畴,调理脾胃是中医临床常用治法。肌肉运动无力为其最突出表现,实质上是骨骼肌的收缩与舒张失常。骨骼肌的收缩和舒张是一种耗能运动,需要线粒体参与供能。研究发现,重症肌无力患者肌肉组织存在线粒体形态结构异常[1],而重症肌无力模型大鼠也存在骨骼肌线粒体结构与功能的改变[2]。线粒体融合分裂不仅在维持线粒体自身的结构功能方面扮演着重要角色,还与神经、骨骼肌病变等密切相关,故有必要从线粒体融合分裂角度,进一步探讨脾胃失调与重症肌无力的相关性。
[Abstract]:Myasthenia gravis is a refractory disease and belongs to the category of "impotence syndrome" of TCM. Regulating spleen and stomach is a common treatment method in TCM. Muscle weakness is the most prominent manifestation of myasthenia gravis. In essence, the contraction and relaxation of skeletal muscle is a kind of energy dissipation movement, which requires mitochondria to participate in energy supply. The study found that the muscle tissue of myasthenia gravis patients had abnormal morphology and structure of mitochondria. [The changes of mitochondria structure and function in skeletal muscle were also found in rats with myasthenia gravis. [2. Mitochondrial fusion and division not only play an important role in maintaining the structure and function of mitochondria itself, but also are closely related to neuropathy and skeletal muscle diseases, so it is necessary to divide from the perspective of mitochondrial fusion. To further explore the relationship between spleen and stomach disorders and myasthenia gravis.
【作者单位】：广州中医药大学脾胃研究所;
【基金】：国家自然科学基金项目(81473568) 广东省中医内科学“特色重点学科建设项目”项目(粤财教[2010]356) 广州中医药大学科研创新基金项目(10CX084);广州中医药大学“薪火计划”(XH20160106)
【分类号】：R277.7
【正文快照】： 重症肌无力(Myasthenia Gravis,MG)是一种神经-肌肉接头(neuromuscular junction,NMJ)传递功能障碍的自身免疫性疾病,病变主要累及NMJ突触后膜上的乙酰胆碱受体(acytylcholine receptor,AChR)。目前研究认为MG的发病机制主要涉及免疫因素和遗传因素,临床治疗MG的方法主要包括

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