疏肝降逆法治疗肝郁型高泌乳素血症的临床观察

发布时间：2018-02-04 18:44

本文关键词： 高泌乳素血症疏肝降逆法肝郁临床观察　出处：《黑龙江中医药大学》2017年硕士论文　论文类型：学位论文

【摘要】：目的:观察评价疏肝降逆法治疗肝郁型高泌乳素血症的临床疗效,并初步探讨其作用机制,为本病寻求一种有效、安全、经济简单的治疗途径。方法:将2015年3月至2016年12月就诊于黑龙江中医药大学附属第二医院妇科门诊,且符合纳入标准的61例肝郁型高泌乳素血症的患者随机分为治疗组(口服丹栀逍遥散加减)31例,对照组(口服溴隐亭)30例。两组患者均以一个月为一疗程,连续治疗3个疗程,观察两组患者用药前后临床症状、中医证候改善情况,血清内分泌激素(PRL、FSH、LH、E2、P)变化,副反应,复发率。结果:两组患者临床总有效率比较,治疗组80.65%,对照组83.33%,经统计学分析,两者并无显著性差异(P0.05);两组患者中医证候疗效比较,治疗组痊愈10例,显效15例,有效4例,无效2例,对照组痊愈4例,显效7例,有效11例,无效8例,治疗组明显优于对照组,且差异性显著(P0.05);治疗组在经行腹胀痛、乳房胀痛、口干口苦等症状方面的改善,显著优于对照组(P0.01);两组患者月经周期情况治疗前后组内比较有显著性差异(P0.05);两组患者血清PRL治疗前后组内比较有非常显著性差异(P0.01),组间比较无显著性差异(P0.05);两组患者FSH、LH治疗前后组内比较无显著性差异(P0.05),E2、P治疗前后组内比较有显著性差异(P0.05);在副反应方面,对照组有7人出现恶心、头晕等不良反应,治疗组未出现,组间比较有显著性差异(P0.05);在副反应方面,治疗组复发率低于对照组。结论:疏肝降逆法治疗肝郁型高泌乳素血症有较好的临床疗效,能够有效的降低患者血清PRL水平,改善患者临床症状,且用药安全,远期效果好,是临床治疗肝郁型高泌乳素血症的有效途径。
[Abstract]:Objective: to observe and evaluate the clinical efficacy of the method of soothing the liver and lowering the inverse in the treatment of hyperprolactinemia of liver depression type, and to explore the mechanism of its action so as to seek an effective and safe method for this disease. Methods: from March 2015 to December 2016, we visited the gynecological outpatient department of the second affiliated Hospital of Heilongjiang University of traditional Chinese Medicine. In addition, 61 patients with hyperprolactinemia of liver depression type were randomly divided into treatment group (31 cases treated by oral administration of Danzhi Xiaoyao Powder plus or subtraction of Dan Zhi Xiaoyao San). Control group (oral bromocriptine 30 cases. Two groups of patients with one month as a course of treatment for 3 consecutive courses of treatment, observe the two groups before and after the treatment of clinical symptoms, TCM syndromes improvement. Results: the total effective rate of the two groups was 80.65% compared with that of the two groups. In the control group, there was no significant difference between the two groups (P 0.05). There were 10 cases of cure, 15 cases of remarkable effect, 4 cases of effective, 2 cases of ineffective in treatment group, 4 cases of cure in control group, 7 cases of remarkable effect, 11 cases of effective and 8 cases of failure. The treatment group was obviously superior to the control group, and the difference was significant (P 0.05). The improvement of symptoms such as abdominal distending pain, breast distending pain and mouth dryness in the treatment group was significantly better than that in the control group (P 0.01). There was significant difference in menstrual cycle between the two groups before and after treatment. There was a very significant difference in serum PRL between the two groups before and after treatment (P 0.01), but there was no significant difference between the two groups (P 0.05). There was no significant difference between the two groups before and after FSHLH treatment. In the side effects, there were 7 cases of nausea, dizziness and other adverse reactions in the control group, but not in the treatment group, there was significant difference between the two groups (P 0.05). In the side effects, the recurrence rate of the treatment group is lower than that of the control group. Conclusion: the treatment of liver depression hyperprolactinemia has a good clinical efficacy, can effectively reduce the serum PRL level of patients. It is an effective way to treat hyperprolactinemia of liver depression type by improving clinical symptoms, safety and long-term effect.
【学位授予单位】：黑龙江中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R259

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