调脂和血颗粒对存在易损斑块的缺血性卒中患者临床干预研究

发布时间：2018-02-05 21:48

本文关键词： 调脂和血颗粒动脉粥样硬化易损斑块二级预防　出处：《山东中医药大学》2016年硕士论文　论文类型：学位论文

【摘要】：目的:通过文献及临床研究,探讨调脂和血颗粒对动脉粥样硬化易损斑块的临床干预效果,从而为化浊行血法治疗中风病痰瘀阻络证提供理论和临床支持。方法:1.理论探讨:广泛搜集、整理古今医家关于血浊理论的论述,搜集当代学者关于血浊与易损斑块及中风痰瘀阻络证相关性的试验及理论研究成果,并在此基础上提出化浊行血治法,阐明血浊理论的内涵、病机及治疗原则。2.临床研究:将62例符合纳入标准的缺血性卒中患者随机分为观察试验组(给予阿司匹林肠溶片100mg/次,1次/日;阿托伐他汀钙片20mg/次,1次/日;调脂和血颗粒6g/次,3次/日)和对照组(给予阿司匹林肠溶片100mg/次,1次/日;阿托伐他汀钙片20mg/次,1次/日),通过3个月治疗,对比两组试验对象治疗前后疗效、实验室指标等变化,分析临床疗效。采用统计软件SPSS17.0处理分析数据。结果:两种治疗方案对动脉硬化易损斑块都有较高疗效,总有效率观察试验组为93%,对照组为83%,观察试验组治疗效果比对照组好。中医临床证候积分比较,观察试验组疗效比对照组更好,有统计学意义(P0.05);在改善中医临床证候积分方面,观察试验组优于对照组,有显著差异(P0.01)。比较试验前后两组患者颈动脉超声,观察试验组对改善患者斑块有显著作用,统计学有显著差异(P0.01),观察试验组卒中的复发及进展脑梗死率低于对照组,差异具有统计学意义。结论:调脂和血颗粒联合西药常规治疗动脉粥样硬化易损斑块比单纯西药治疗效果更显著,能较大程度上改善临床症状,是临床治疗存在易损斑块缺血性卒中患者的有效临床途径。
[Abstract]:Objective: to investigate the clinical intervention effect of Tiaozhi and Xue granule on atherosclerotic vulnerable plaque through literature and clinical research. Thus, it provides theoretical and clinical support for the treatment of phlegm and blood stasis syndrome of apoplexy. Methods: 1. Theoretical discussion: extensive collection, collation of ancient and modern physicians on the theory of blood turbidity. Collection of contemporary scholars on the relationship between blood turbidity and vulnerable plaque and apoplexy phlegm and blood stasis syndrome related to the experimental and theoretical research, and on the basis of the proposed method of blood treatment, to clarify the connotation of the theory of blood turbidity. Clinical study: 62 patients with ischemic stroke who met the inclusion criteria were randomly divided into the observation group (100 mg / d aspirin enteric-coated tablets once a day); The calcium tablets of Atto vastatin were 20mg / day; Tiaozhi Hexue granule (6g / d) and control group (100mg / d aspirin enteric-coated tablets were given once a day); Atto vastatin calcium tablets were treated once a day with 20mg / d for 3 months. The efficacy and laboratory indexes were compared between the two groups before and after treatment. Analysis of clinical efficacy. The statistical software SPSS17.0 was used to process the analysis data. Results: both of the two treatment regimens had higher curative effect on arteriosclerotic vulnerable plaque, the total effective rate was 93% in the experimental group. The therapeutic effect of the observation group was better than that of the control group, and the curative effect of the observation group was better than that of the control group (P 0.05). In improving the TCM clinical syndrome score, the observation group is better than the control group, there is a significant difference between the two groups before and after the comparison of the two groups of carotid artery ultrasound. The observation group had significant effect on improving the plaque of patients, there was significant difference between the two groups (P 0.01). The rate of stroke recurrence and progressive cerebral infarction in the observation group was lower than that in the control group. The difference is statistically significant. Conclusion: Tiaozhi and Xue granule combined with western medicine routine treatment of atherosclerotic vulnerable plaque is more effective than the treatment of western medicine alone, can improve the clinical symptoms to a greater extent. It is an effective clinical approach for the treatment of ischemic stroke patients with vulnerable plaque.
【学位授予单位】：山东中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R277.7

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