基于体素的静息态fMRI观察原发性失眠患者针刺治疗后全脑度中心度的改变

发布时间：2018-02-07 09:33

本文关键词： 静息态功能磁共振原发性失眠脑功能网络度中心度　出处：《中山大学学报(医学科学版)》2017年02期 　论文类型：期刊论文

【摘要】：【目的】利用度中心度(DC)的方法探讨原发性失眠(PI)患者针灸治疗后静息态下脑功能网络连接属性的改变。【方法】对29例PI患者及22例年龄、性别、受教育程度均匹配的健康对照组进行百会、四神聪、神门、三阴交等穴位行两周针灸治疗后,行静息状态下的功能磁共振成像扫描,经预处理和后处理计算出全脑DC值图,采用双样本t检验进行组间比较,分别检测PI组与NC组间DC分布图间的统计学差异。【结果】与NC组相比,PI患者DC值减低的脑区主要分布在右侧颞中回、右侧海马、右侧豆状核、双侧海马旁回及左侧楔叶等区域。【结论】基于静息态功能MRI数据的DC分析观察到PI患者在脑区间功能连接改变,DC作为一种新的基于体素水平描述脑网络属性的方法,可能对理解PI神经机制及观察其脑网络属性的改变提供了一个新视角。
[Abstract]:[objective] to investigate the changes of brain functional network connection properties in patients with primary insomnia (PI) after acupuncture and moxibustion. [methods] 29 patients with Pi and 22 patients with age and sex were studied. After two weeks of acupuncture and moxibustion treatment at Baihui, Sishen Cong, Shenmen and Sanyinjiao, the healthy control group with matched educational level were scanned by functional magnetic resonance imaging (fMRI) in resting state, and the whole brain DC value was calculated by pretreatment and postprocessing. The difference of DC distribution between Pi group and NC group was detected by double sample t test. [results] the decreased DC value of Pi patients was mainly distributed in the right middle temporal gyrus, right hippocampus, right lentiform nucleus, compared with NC group. [conclusion] DC analysis based on resting functional MRI data shows that the change of functional junctions in the brain of Pi patients is a new method to describe the properties of brain network based on voxel level. It may provide a new perspective for understanding Pi neural mechanism and observing the changes of brain network properties.
【作者单位】：慈溪市人民医院;新疆维吾尔自治区人民医院北院;广东省第二人民医院;
【基金】：广州市科技计划项目(201607010056) 慈溪市科技计划项目(CN2014033)
【分类号】：R246.6

【相似文献】