参芪桂附活血方治疗心肾阳虚型病态窦房结综合征的临床研究

发布时间：2018-02-08 23:05

本文关键词： 参芪桂附活血方心肾阳虚病态窦房结综合征临床研究参芪桂附活血方心肾阳虚病态窦房结综合征临床研究　出处：《山东中医药大学》2016年硕士论文　论文类型：学位论文

【摘要】：目的:观察参芪桂附活血方对心肾阳虚型病窦综合征患者的临床疗效,探讨该方的作用机理,评价疗效及安全性,为临床治疗病窦综合征提供实际而有价值的治疗途径。方法:选取山东中医药大学第一附属医院心内科门诊及综合内科住院病例,根据纳入和排除标准选择60例。采用前瞻性的随机对照研究,分为试验组与对照组。两组患者的一般情况无统计学差异。对照组给予心宝丸合西医常规治疗,试验组在常规西医治疗基础上加服参芪桂附活血方,一日一剂,分早晚饭后半小时温服。4周后进行各项临床疗效评定。观察并对比两组患者治疗前后的中医单项症状总积分及中医症状总积分、心率疗效比较、静息心电图。观察比较两组患者治疗前后肝肾功的变化。结果:经过4周的治疗,临床研究证实,试验组在心率疗效方面、中医症状总疗效方面优于对照组(P0.05);中医单项症状疗效分析表明:试验组在头晕、乏力、畏寒、肢冷面色苍白方面的改善情况显著优于对照组(P0.01),试验组在心悸、胸闷、头晕、气短、乏力、畏寒、肢冷、面色苍白、舌暗苔白、脉结代等方面的改善情况优于对照组(P0.05);试验组与对照组静息心电图(S-T段、T波)组间、组内比较均无明显变化(P0.05)。试验组及对照组治疗前后肝肾功能均无明显变化(P0.05)?结论:参芪桂附活血方能改善SSS患者的临床症状,提高其生活质量,其安全性和耐受性良好,值得进一步应用和推广?
[Abstract]:Objective: to observe the clinical effect of Shenqi Gui Fu Huoxue recipe on patients with sinusoidal syndrome with deficiency of heart and kidney yang, to explore its mechanism, to evaluate the efficacy and safety. Objective: to provide a practical and valuable approach for the treatment of sinus syndrome. Methods: the patients in cardiology outpatient department and general internal medicine department of the first affiliated Hospital of Shandong University of traditional Chinese Medicine were selected. According to the criteria of inclusion and exclusion, 60 cases were selected and divided into two groups by prospective randomized controlled study. There was no statistical difference in general conditions between the two groups. The control group was treated with Xinbao Pill combined with routine western medicine. The experimental group was treated with Shenqi Gui Fu Huoxue recipe on the basis of routine western medicine treatment, one dose in 1st. The clinical curative effect was evaluated half an hour after meals in the morning and evening. The total symptom score of TCM and the total score of TCM symptom and the curative effect of heart rate were observed and compared between the two groups before and after treatment. Observe and compare the changes of liver and kidney function before and after treatment in the two groups. Results: after 4 weeks of treatment, the clinical study confirmed that the experimental group was effective in heart rate. The total curative effect of TCM was better than that of the control group (P0.05A), the analysis of the curative effect of single TCM symptom showed that the improvement in dizziness, fatigue, chills, cold and pale limbs in the test group was significantly better than that in the control group (P 0.01), and the palpitations, chest tightness, dizziness in the experimental group were better than those in the control group. The improvement of shortness of breath, fatigue, chills, cold limbs, pale complexion, white tongue coating and pulse node generation were better than those in control group (P 0.05), and between the experimental group and the control group, the S-T segment T wave of resting electrocardiogram was increased. There was no significant change in the liver and kidney function before and after treatment in the experimental group and the control group, and there was no significant change in the liver and kidney function in the experimental group and the control group before and after treatment. Conclusion: Shenqi Gui Fu Huoxue Formula can improve the clinical symptoms and improve the quality of life of patients with SSS, and its safety and tolerance are good, which is worthy of further application and promotion.
【学位授予单位】：山东中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259

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