滋阴活血方治疗2型糖尿病阴虚血瘀的临床研究

发布时间：2018-02-11 00:10

本文关键词： 滋阴活血方 2型糖尿病阴虚血瘀中医药治疗　出处：《南京中医药大学》2017年硕士论文　论文类型：学位论文

【摘要】：目的:使用滋阴活血方联合西药常规治疗进行临床观察,与单纯使用糖尿病西药常规治疗进行比较。为糖尿病治疗提供更多的方案选择。控制疾病进展,改善并发症,提高生活质量。.方法:对133例符合2型糖尿病(T2DM)阴虚血瘀诊断标准的患者进行临床观察。以滋阴活血方联合西药常规治疗为治疗组,以单纯西药常规治疗为对照组。分析记录患者治疗后1个月的临床疗效:身体质量指数(BMI)、空腹血糖(FPG)、餐后2小时血糖(2hPG)、糖化血红蛋白(HbA1C)、总胆固醇(TC)、.甘油三酯(TG)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)、空腹胰岛素(FINS)、餐后2小时胰岛素(2hINS)、空腹C肽水平(FCP)、餐后2小时C肽(2hCP),谷丙转氨酶(ALT),谷草转氨酶(AST),尿微量白蛋白(mA1b),以及临床症候积分。结果:(1)治疗后,治疗组症候总积分较对照组明显降低(P0.05),且其总有效率高于对照组。(2)治疗后,对照组的空腹血糖和餐后2小时血糖较治疗前降低(P0.05)。治疗组的空腹血糖、餐后2小时血糖、糖化血红蛋白均低于治疗前(P0.05);且均较对照组降低(P0.05)。治疗前后两组患者的体质量指数未见差异(P0.05)。(3)治疗后,治疗组的空腹及餐后C肽和胰岛素均较治疗前明显增加(P0.05),上述数据在对照组未见有效变化(P0.05)。且治疗组治疗后空腹及餐后胰岛素水平较对照组升高明显(P0.05)。(4)治疗后,治疗组的总胆固醇、甘油三酯、低密度脂蛋白均有所降低(P0.05),且总胆固醇、甘油三酯下降幅度较对照组明显(P0.05),对照组的相关数据无明显改变(P0.05)。两组患者高密度脂蛋白在治疗前后无统计学意义。(5)两组患者治疗前后谷丙转氨酶、谷草转氨酶及尿微量白蛋白数值均未见明显变化(P0.05),且治疗期间均未发生低血糖症状。结论:阴虚血瘀证型糖尿病患者联合滋阴活血方治疗,能有效改善患者临床症状,降低血糖、糖化血红蛋白,降低患者血脂,改善脂质代谢紊乱情况,且对患者肝肾功能无明显影响。临床应用相对安全。
[Abstract]:Objective: to observe the clinical effects of Ziyin Huoxue recipe combined with routine western medicine, and to provide more options for diabetes treatment, to control the progress of the disease and to improve the complications, compared with the routine treatment of diabetes mellitus. Methods: 133 patients who met the diagnostic criteria of yin deficiency and blood stasis in type 2 diabetes mellitus T2DM.Methods: the treatment group was treated with Ziyin Huoxue recipe combined with routine western medicine. In the control group, routine therapy of western medicine was used as the control group. The clinical effects of 1 month after treatment were analyzed and recorded: body mass index (BMI), fasting blood glucose (FPG), 2 h postprandial blood glucose (GPG), HbA1C (glycosylated hemoglobin), total cholesterol (TC), triglyceride (TGG), low levels of triglyceride (TGG). LDLX, HDL, FINSN, 2hINSN, FCPP, 2hCPT, ALT, ASTT, urinary albumin mA1bT, and the clinical symptom score of the two hours postprandial C peptide, alanine aminotransferase (alt), aspartate aminotransferase (ASTT), urinary albumin mA1bU, and clinical symptoms. After treatment, The total symptom score of the treatment group was significantly lower than that of the control group, and the total effective rate was higher than that of the control group.) after treatment, the fasting blood glucose and 2 hours postprandial blood glucose in the control group were lower than those before treatment. The fasting blood glucose and 2 hours postprandial blood glucose in the treatment group were lower than those before treatment. The levels of glycosylated hemoglobin were lower than those of the control group before and after treatment. There was no difference in body mass index (BMI) between the two groups before and after treatment. The fasting and postprandial C peptide and insulin levels in the treatment group were significantly higher than those before treatment. The above data had no significant change in the control group. The fasting and postprandial insulin levels in the treatment group were significantly higher than those in the control group. The total cholesterol, triglyceride and low density lipoprotein in the treatment group were all decreased, and the total cholesterol, The decrease of triglyceride was significantly higher than that of the control group (P 0.05), and there was no significant change in the data of the control group. There was no significant difference in serum alanine aminotransferase between the two groups before and after treatment. Glutamic oxaloacetic transaminase and urinary microalbumin were not significantly changed, and no hypoglycemia symptoms occurred during the treatment. Conclusion: the combination of Ziyin Huoxue recipe for diabetes with yin deficiency and blood stasis syndrome can effectively improve the clinical symptoms of the patients. Lowering blood sugar, glycosylated hemoglobin, lowering blood lipid, improving the disorder of lipid metabolism, and has no obvious effect on the liver and kidney function of patients, clinical application is relatively safe.
【学位授予单位】：南京中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R259

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